Nouvelles nanostructures vésiculaires pour l'administration topique de médicaments
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Nouvelles nanostructures vésiculaires pour l'administration topique de médicaments

Nouvelles nanostructures vésiculaires pour l'administration topique de médicaments


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About the Book

Le plus grand défi rencontré par l'administration topique est la nature de la barrière de la peau elle-même qui limite la biodisponibilité (BA) des médicaments administrés par voie topique. L'administration de médicaments par des supports nano-vésiculaires est une stratégie appropriée pour améliorer la BA. Des approches récentes ont abouti à la conception de nouveaux supports vésiculaires déformables qui peuvent pénétrer à travers les couches plus profondes de la peau en raison de leur élasticité et de leur taille nanométrique. Des études ont suggéré que la présence d'activateurs de bord tels que les tensioactifs et l'éthanol déstabilise les bicouches lipidiques et augmente la déformabilité des vésicules, mais ces supports présentent certains inconvénients tels que l'irritation de la peau.Sur la base de ces considérations, ce livre propose donc une nouvelle méthode pour modifier les liposomes en incorporant du glycérol comme activateur de bord.Le glycérol est choisi parce qu'il est largement utilisé dans les formulations topiques, la présence de groupes hydroxyles, l'effet plastifiant connu, et la bonne propriété de solvant. L'objectif de ce travail est de concevoir et de développer de nouvelles nanostructures vésiculaires qui surmonteront les limites des systèmes vésiculaires existants et offriront une valeur potentielle dans l'administration topique de médicaments et de cosmétiques. La Rhodamine B est choisie comme médicament modèle.


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Product Details
  • ISBN-13: 9786205615294
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 100
  • Spine Width: 6 mm
  • Width: 152 mm
  • ISBN-10: 6205615290
  • Publisher Date: 24 Jan 2023
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 209 gr


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