ГИГАНТОКЛЕТОЧНЫЕ ПОРАЖЕНИЯ
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ГИГАНТОКЛЕТОЧНЫЕ ПОРАЖЕНИЯ

ГИГАНТОКЛЕТОЧНЫЕ ПОРАЖЕНИЯ


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About the Book

Гигантская клетка - это масса, образованная объединением нескольких отдельных клеток (обычно макрофагов), которые подвергаются определенному набору межклеточных взаимодействий, что в конечном итоге приводит к образованию многоядерной клетки с одним цитоплазматическим отделением. Многоядерные клетки часто встречаются при поражениях полости рта и челюстно-лицевой области. Впервые многоядерные гигантские клетки были обнаружены в туберкулезных гранулемах Рокитанским и Лангхансом более века назад. В настоящее время эти гигантские клетки признаны общим признаком гранулемы, индуцированной иммунологическими и неиммунологическими стимулами. Таким образом, они встречаются в гранулемах, связанных с иммунным ответом на туберкулез, проказу, сифилис и различные грибковые и паразитарные инфекции, а также в гранулемах, связанных с неиммунным ответом на токсичные агенты, такие как кремнезем, бериллий и асбест, и два нетоксичных агента, таких как частицы углерода, пластиковые шарики и частицы железа. Недавние исследования с участием многих остеокластов и гигантских клеток инородных тел выявили ряд общих факторов, например, витронектин, белок адгезии, специфический трансмембранный белок дендритных клеток (DC- STAMP), фактор слияния и рецептор слияния макрофагов, которые способствуют образованию гигантских клеток.


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Product Details
  • ISBN-13: 9786204097787
  • Publisher: Sciencia Scripts
  • Binding: Paperback
  • Language: Russian
  • Returnable: N
  • Weight: 281 gr
  • ISBN-10: 6204097784
  • Publisher Date: 21 Sep 2021
  • Height: 229 mm
  • No of Pages: 152
  • Spine Width: 9 mm
  • Width: 152 mm


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