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Генная терапия для лечения рака молочно&#108

Генная терапия для лечения рака молочноl


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About the Book

Рак молочной железы является наиболее распространенным типом неоплазии у женщин. Большинство наследственных случаев связано с мутациями связанных с раком молочной железы генов (BRCA). Профилактическая мастэктомия и химиопрофилактика являются на сегодняшний день единственными доступными подходами для предотвращения развития новообразований у пациентов со специфическим генетическим фоном. Однако побочные эффекты и инвазивность этих процедур делают необходимым разработку альтернативных стратегий. В этой книге описывается новый подход к профилактике рака молочной железы, основанный на восстановлении функционального гена BRCA1 в клетках-мишенях с помощью инжинирингового вируса. Фактически, вирусы разработали эффективный механизм доставки своего генетического материала в клетки-мишени; вирусные векторы используют преимущества этой способности для транспортирования трансгенных клеток. С этой целью был создан лентивирусный вектор, экспрессирующий ген BRCA1. Восстановление функции гена подтверждено в опухолевых и первичных клетках, полученных от пациента, кодирующего неактивную форму BRCA1, которая после доставки гена восстанавливает способность восстанавливать повреждения ДНК при экспозиции к ионизирующему излучению Эти результаты прокладывают путь к разработке новых профилактических подходов к борьбе с раком молочной железы человека.


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Product Details
  • ISBN-13: 9786202959445
  • Publisher: Sciencia Scripts
  • Binding: Paperback
  • Language: Russian
  • Returnable: N
  • Weight: 190 gr
  • ISBN-10: 6202959444
  • Publisher Date: 22 Oct 2021
  • Height: 229 mm
  • No of Pages: 88
  • Spine Width: 5 mm
  • Width: 152 mm


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