18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway
18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway

18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway


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About the Book

Opioid addiction is a major public health problem and the need for new efficient therapies is immense.18-Methoxycoronaridine (18-MC), an iboga alkaloid congener, has been previously shown to reduce the self-administration of several drugs of abuse, including opioids.18-MC is a potent antagonist of alpha3beta4 nicotinic receptors and this now appears to be the primary mechanism of 18- MC's action in the brain. These nicotinic receptors are present in high densities in the nuclei of the habenulo-interpeduncular pathway but not in the mesolimbic pathway, known to be involved in drug addiction.This book describes the modulation of the mesolimbic pathway by the habenulo- interpeduncular pathway during chronic exposure to opioids and examines the role of 18-MC, nicotinic receptors and acetylcholine in such modulation.This book also illustrates the contribution of the latter pathway in 18-MC's ability to attenuate opioid withdrawal.The findings described in the book provide evidence that alpha3beta4 nicotinic receptors could be a novel target for anti-addictive therapies.The monograph should be useful to pharmacologists and behavioral neuroscientists.


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Product Details
  • ISBN-13: 9783639137743
  • Publisher: VDM Verlag
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 340 gr
  • ISBN-10: 3639137744
  • Publisher Date: 26 Jun 2009
  • Height: 229 mm
  • No of Pages: 192
  • Spine Width: 11 mm
  • Width: 152 mm


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18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway
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18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway
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