Activité anti-stress du RNH-12 (dérivé de l'hydrazone de l'acide arylique)
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Activité anti-stress du RNH-12 (dérivé de l'hydrazone de l'acide arylique)

Activité anti-stress du RNH-12 (dérivé de l'hydrazone de l'acide arylique)


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About the Book

Objectif: La présente étude a été entreprise pour évaluer l'effet anti-stress du RNH-12 sur le stress expérimental induit chez le rat.Méthodologie: L'effet anti-stress a été évalué sur le stress induit par la contention par le froid et sur le stress induit par l'endurance à la nage. Le RNH-12 a été administré par voie orale à deux doses différentes de 40 et 60 mg/kg. Withania somnifera, une formulation anti-stress connue (500 mg/kg p.o.) a été utilisée comme médicament standard.Résultats: Les deux doses de RNH-12 ont montré un bon effet anti-stress dans tous les modèles animaux testés. Le RNH-12 a réduit le développement d'ulcères gastriques induits par la contention par le froid et a empêché les changements biochimiques induits par l'endurance à la natation et le stress de l'endurance à la natation, tels que l'augmentation des niveaux plasmatiques d'aspartate aminotransférase, d'alanine aminotransférase, de phosphatase alcaline, de glucose, de cholestérol et de Cortiosol. Le RNH-12 a également été efficace pour augmenter la latence des convulsions induites par le stress anoxique chez le rat.Conclusion: Le médicament expérimental RNH-12 à des doses de 40 et 60 mg/kg par voie orale possède une bonne activité anti-stress.


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Product Details
  • ISBN-13: 9786206847014
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 145 gr
  • ISBN-10: 6206847012
  • Publisher Date: 18 Nov 2023
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm


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