1. Adeno-Associated Virus Biology
Matthew D. Weitzman and R. Michael Linden
2. Design and Construction of Functional AAV Vectors
John T. Gray and Serge Zolotukhin
3. AAV Capsid Structure and Cell Interactions
Jürgen Kleinschmidt and Mavis Agbandje-McKenna
4. Exploiting Natural Diversity of AAV for the Design of Vectors With Novel Properties
Guangping Gao, Li Zhong, and Olivier Danos
5. Gene Therapy in Skeletal Muscle Mediated by Adeno-Associated Virus (AAV) Vectors
Chunping Qiao, J. George Dickson, Juan Li, Taeyoung Koo, and Xiao Xiao
6. AAV-Mediated Liver-Directed Gene Therapy
Mark S. Sands
7. Recombinant AAV Delivery to the Central Nervous System
Olivier Bockstael, Kevin Foust, Brian Kaspar, and Liliane Tenenbaum
8. AAV Mediated Gene Therapy for Retinal Degenerative Diseases
Knut Stieger, Therese Cronin, Jean Bennett, and Fabienne Rolling
9. Adeno-Associated Virus Vector Delivery to the Heart
Lawrence T. Bish, H. Lee Sweeney, Oliver J. Müller, and Raffi Bekeredjian
10. Evaluation of the Fate of rAAV Genomes Following in vivo Administration
K. Reed Clark and Magalie Penaud-Budloo
11. Measuring Immune Responses to Recombinant AAV Gene Transfer
Ashley T. Martino, Ignacio Anegon, Oumeya Adjali, and Roland W. Herzog
12. Modification and Labeling of AAV Vector Particles
Hildegard Büning, Chelsea M. Bolyard, Michael Hallek, and Jeffrey S. Bartlett
13. AAV-mediated Gene Targeting
Daniel G. Miller
14. Preclinical Study Design for rAAV
Terence R. Flotte, Thomas J. Conlon, and Christian Mueller
15. Biodistribution and Shedding of AAV Vectors
Caroline le Guiner, Philippe Moullier, and Valder R. Arruda
16. Production and Purification of Recombinant Adeno-Associated Vectors
Lijun Wang, Véronique Blouin, Nicole Brument, Mahajoub Bello-Roufai, and Achille Francois
17. rAAV Vector Product Characterization and Stability Studies
Richard O. Snyder, Muriel Audit, and Joyce D. Francis
18. rAAV Human Trial Experience
Katherine A. High and Patrick Aubourg
