Section I: The Epidemiology of Alcohol Use and Lung Health
Chapter 1
A Brief History of Alcohol Use and Abuse in Human History
David M. Guidot, MD, Ashish J. Mehta, MD, MSc
Chapter 2
Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations
David M. Guidot, MD, Ashish J. Mehta, MD, MSc
Chapter 3
Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research
Karen Drexler, M.D
Chapter 4
The Epidemiology of Alcohol Abuse and Pneumonia
Kyle I. Happel, M.D
Chapter 5
The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome
Brendan J. Clark, MD and Ellen L. Burnham, MD, MS
Section II: The Pathophysiology of the 'Alcoholic Lung'
Chapter 6
Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways
Todd A. Wyatt, PhD and Joseph H. Sisson, MD
Chapter 7
Alcohol and the Alveolar Macrophage
Samantha M. Yeligar, MS, PhD; Yan Liang, PhD; Lou Ann S. Brown, PhD
Chapter 8
Alcohol and the Alveolar Epithelium
Samuel Molina, Ph.D. and Michael Koval, Ph.D.
Chapter 9
Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion
Samantha M. Yeligar, MS, PhD; Yan Liang, PhD; and Lou Ann S. Brown, PhD
Chapter 10
Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments
Kevin L. Legge, PhD* and Thomas J. Waldschmidt, PhD
Chapter 11
Alcohol Impairment of Granulocyte Function During Lung Infection
Gregory J. Bagby, Ph.D., Kyle Happel, MD, J Nicholas Melvan, MD, Ph.D
Chapter 12: Disruption in the Dynamic Balance Between Transforming Growth Factor-β and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function
David M. Guidot, MD, Ashish J. Mehta, MD, MSc
Chapter 13
Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung
Ashish J. Mehta, MD, MSc, David M. Guidot, MD
Section III: Special Circumstances
Chapter 14
The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient
Katharina Chalk, MD
Claudia Spies, MD
Chapter 15
Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung
Sushma K. Cribbs, MD, David Rimland, MD
Chapter 16
Maternal Alcohol Use and the Neonate
Theresa W. Gauthier, MD, Danielle Giliberti, MD, PhD
Sowmya S. Mohan, MD, Juna Konomi, BA, Lou Ann S. Brown, PhD
