Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.
About the Author: Andrei Medvedovici: born Nov. 29',1961; 1984 - B.Sc. in Chemistry, Polytechnic University of Bucharest, Faculty of Chemistry; 1985 - M.Sc. in Analytical Chemistry, Polytechnic University of Bucharest, Faculty of Chemistry; 1992 - pre-doctoral stage at the University of Ghent -Belgium; 1994 - Ph.D. in Chemistry, University of Bucharest, Faculty of Chemistry; 1994 - 1997 post-doctoral studies at the University of Ghent -Belgium and Research Institute for Chromatography, Kortrijk, Belgium (coordinator: Prof. Dr. Pat Sandra); from 1990 at the University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry (teaching assistant, lecturer, associated professor); from 2005 professor at the same institution; from 2006, Ph.D. coordinator (same institution); 2002-2009 - R&D director, Labormed Pharma; from 2009 - Scientific director, Labormed Group; Editorial board member at Bioanalysis and Journal of Liquid Chromatography & Related Technologies; 2009 - Prize C.D. Nenitescu of the Romanian Academy for the cycle of publications on applications of LC/MS in biomedical field; lSI publications: 86 (72 abroad Romania); non-lSI publications: 13 (12 abroad Romania); published courses, contributions in monographs and encyclopedias: 25 (14 abroad Romania); cumulated impact factor: - 140; citation index: 491; h-index: 12.
Victor David: born February 261h 1955; 1979 - B.Sc. in Chemistry, Polytechnic University of Bucharest, Faculty of Chemistry; 1980 - M.Sc. in Analytical Chemistry, Polytechnic University of Bucharest, Faculty of Chemistry; 1989 - Ph.D. in Chemistry, Polytechnic University of Bucharest, Faculty of Chemistry; from 1992, in the Analytical Department of the Faculty of Chemistry, University of Bucharest (1992 - lecturer, 1997 - associated professor, 2002 - professor, 2005 - Ph.D. cooridination); Editorial board member at Journal of Essential Oils Bearing Plants and Open Automation and Control Systems Journal (Bentham Publishers); 2004 - Prize I.G. Murgulescu of the Romanian Academy; lSI publications: 90 (56 abroad Romania); non-lSI publications: 11 (2 abroad Romania); published courses: 8; monographs: 1 (abroad Romania); chapters in monographs and encyclopedias: 8 (8 abroad Romania); cumulated impact factor: > 1 00; citation index: > 270; h-index: 9.
