Part I: Introduction

Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?

Lois A. Lampson

Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints

José M. Orellana-Muriana

Part II: Animal Models Offer Insights into Human Brain Neoplasms

The VM Mouse Model of Glioblastoma Multiforme

Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt

Oligodendroglioma Models

Nanna Lindberg and Lene Uhrbom

Medulloblastoma Model

Jasmine Lau and William A. Weiss

Learning about Retinoblastoma from Mouse Models that Missed

David Cobrinik

Ependymoma Models

Jesús Vaquero and Mercedes Zurita

Meningioma Models

Jessica Rainey and Randy L. Jensen

Pituitary Models

Walavan Sivakumar and William T. Couldwell

Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors

Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha

Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models

Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children

Aparna Kaul, Ibrahim Hussain, and David H. Gutmann

EGFR and Tumor-Suppressor Function in Brain Cancer Development

Julie Lessard and Al Charest

Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models

Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts

Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro

Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models

Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell

Assessing Mechanisms of Glioblastoma Invasion

Stephen M. Robbins and Donna L. Senger

Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism

Positron Emission Tomography (PET)-Based Molecular Imaging

Yannic Waerzeggers, Thomas Viel, Sonja Schäfers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schäfers, and Andreas H. Jacobs

In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)

Rui V. Simões, Ana Paula Candiota, Margarida Julià-Sapé, and Carles Arús

Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research

André Constantinesco, Christian Goetz, and Philippe Choquet