Providing a spectrum of models that is reflective of the various species that can be utilized in experimentation on disorders across a broad range of developmental disabilities, this volume collects expert contributions involved in investigation of the causes, outcomes, treatment, and prevention. Animal Models of Neurodevelopmental Disorders explores models of perinatal hypoxia-ischemia/cerebral palsy and stroke, autism spectrum disorder, fetal alcohol syndrome, as well as mental retardation. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.
Practical and authoritative, Animal Models of Neurodevelopmental Disorders serves to introduce and entice those interested in better understanding and treating these disorders to the vital animal model world of investigation.
About the Author: "Series Preface"
"Preface"
"Contributors"
1. Unilateral Common Carotid Artery Ligation as a Model of Perinatal Asphyxia: The Original Rice-Vannucci Model
Antoinette Nguyen, Edward A. Armstrong, and Jerome Y. Yager
2. Bilateral Uterine Artery Ligation (BUAL): Placental Insufficiency Causing Fetal Growth Restriction and Cerebral Palsy
Jennifer Corrigan, Edward A. Armstrong, Stuart Faulkner, Crystal A. Ruff, Michael Fehlings, and Jerome Y. Yager
3. Perinatal Intracerebral Hemorrhage Model and Developmental Disability
Janani Kassiri and Marc R. Del Bigio
4. Rabbit Kit Model of Glycerol-Induced Intraventricular Hemorrhage
Praveen Ballabh
5. Models of Perinatal Brain Injury in Premature and Term Newborns Resulting from Gestational Inflammation Due to Inactivated Group B Streptococcus (GBS), or lipopolysaccharide (LPS) from E. coli" "and/or Immediately Post-Natal Hypoxia-Ischemia (HI)
Julie Bergeron, Marie-Julie Allard, Clemence Guiraut, Mathilde Chevin, Alexandre Savard, Djordje Grbic, Marie-Elsa Brochu, and Guillaume Sebire
6. Fetal Brain Activity in the Sheep Model with Intra-Uterine Hypoxia
Bryan S. Richardson and Brad Matushewski
7. Studies of Perinatal Asphyxial Brain Injury in the Fetal Sheep
Paul Drury, Laura Bennet, Lin Booth, Joanna Davidson, Guido Wassink, and Alistair Jan Gunn
8. The Sheep as a Model of Brain Injury in the Premature Infant
Stephen A. Back, Art Riddle, and A. Roger Hohimer
9. The Rabbit as a Model of Cerebral Palsy
Kehuan Luo, Jessica Baker, Matthew Derrick, and Sidhartha Tan
10. A Newborn Piglet Survival Model of Post-Haemorrhagic Ventricular Dilatation (PHVD)
Kristian Aquilina and Marianne Thoresen
11. Physiologic Aspects of the Piglet as a Model of Perinatal Hypoxia and Reoxygenation
Richdeep S. Gill, David L. Bigam, and Po-Yin Cheung
12. The Newborn Pig Global Hypoxic-ischemic Model of Perinatal Brain and Organ Injury
Elavazhagan Chakkarapani and Marianne Thoresen
13. Animal Models of Fetal Alcohol Spectrum Disorder
Wendy Comeau, Tamara Bodnar, Kristina Uban, Vivian Lam, Kasia Stepien, and Joanne Weinberg
14. Modeling Mental Retardation in Drosophila
Francois V. Bolduc
15. Animal Models of Cerebral Dysgenesis: Excitotoxic Brain Injury
Luigi Titomanlio, Leslie Schwendimann, and Pierre Gressens
16. The Effect of Age on Brain Plasticity in Animal Models of Developmental Disability
Bryan Kolb and Deborah Saucier"
