Part 1. General Principles.- Physiology of Hemostasis.- Laboratory Assessment of Physiologic and Pathologic Hemostasis.- Current Anticoagulation Drugs and Mechanisms of Action.- Reversal of Target-Specific Oral Anticoagulants.- Overview, Treatment, Measurement, and Modification of Platelet Function.- Role of Antiplatelet Therapy in Neurosurgery: Efficacy and Safety Profiles.- Part 2. Coagulation Issues Across all Patient Spectrums.- Congenital Coagulation Disorders.- Acquired Coagulation Disorders.- Regulation and Dysregulation of Fibrinolysis.- Risks Associated with Administration of Allogeneic Blood Components.- Common Coagulation Disorders That May Arise Intraoperatively.- Evaluation and Management of Untoward Intraoperative Bleeding.- Treatment of Disseminated Intravascular Coagulation (DIC).- Heparin-Induced Thrombocytopenia (HIT).- Anticoagulation in Cardiovascular Diseases.- Workup and Treatment of Pulmonary Embolus .- Part 3. Coagulation Issues Specific to Neurosurgery.- Classes of Drugs and Blood Products for Acute Reversal of Anticoagulant Effect.- Rescue Strategies to Facilitate Emergency Neurosurgery in Patients on Antiplatelet or Anticoagulant Agents.- Considerations for Coagulation in the Multi‐Trauma Patient.- Cerebral Venous Sinus Thrombosis.- Coagulation Studies in Preoperative Neurosurgery Patients.- Safe Strategies for Gradual Suspension and Re-institution of Anticoagulation to Permit Elective Surgery.- Spontaneous Intracerebral Hemorrhage due to Coagulation Disorders.- Prophylactic Screening for Venous Thromboembolism in Neurosurgical Patients.- Venous Thromboembolism Prophylaxis in Neurosurgery.- Can Patients with Known Intracranial and Intraspinal Vascular Lesions be Anticoagulated?.- Intrathecal Access and Devices in Patients on Antiplatelet or Anticoagulant Therapy.- Is it Safe to Shunt Anti-coagulated NPH Patients?.- Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary.
About the Author: Christopher M. Loftus, MD, Dr.h.c., FACS, is Professor and Chairman, Department of Neurosurgery, and Professor of Neurology at Loyola University Stritch School of Medicine, Maywood, IL, USA. His previous appointments include Professor and Chairman, Department of Neurosurgery, Temple University School of Medicine, Philadelphia, PA; The Harry Wilkins Professor and Chairman and The Esther and Ted Greenberg Professor and Chairman, Department of Neurosurgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; and Professor of Surgery (Neurosurgery), The University of Iowa College of Medicine, Iowa City, IA. Dr. Loftus is a Diplomate of the National Board of Medical Examiners and the American Board of Neurological Surgery. He has held many offices in leading professional bodies, including Vice Presidency of the American Association of Neurological Surgeons, and he is currently Treasurer of the World Federation of Neurosurgical Societies. His research interests include intracranial collateral circulation, extracranial carotid occlusive disease, and responses of cerebral blood flow to cerebral revascularization. He is participating in the IHAST cooperative trial for hypothermia in aneurysm surgery and the ISUIA - unruptured aneurysm trial. Dr. Loftus has been a member of the editorial boards of many prestigious journals and is the author of more than 200 articles and book chapters in peer-reviewed publications. He has edited or authored over twenty previous books, including, most recently, Intraoperative Neuromonitoring (McGraw-Hill, New York, 2013; co-editors Biller J and Baron EF).