Antimicrobial Therapeutics Reviews
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Antimicrobial Therapeutics Reviews: The Bacterial Cell Wall as an Antimicrobial Target

Antimicrobial Therapeutics Reviews: The Bacterial Cell Wall as an Antimicrobial Target

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About the Book

Bacterial cell walls are unique structures that serve as ideal targets for antimicrobial drugs. Agents that interfere with bacterial cell wall biosynthesis or cell integrity have been used therapeutically with high efficacy and good safety since the 1940s.Because there is no comparable structure in mammalians, bacterial cell wall inhibitors can exhibit high target specificity with side effect profiles that are not target related, unlike some other classes of antibiotics. In addition, cell wall active agents are frequently bactericidal in their action, providing the opportunity for complete bacterial clearance in serious infections. In this Annals volume, the contributors explore the various roles of the bacterial cell wall as related to the physiology of bacteria and to the development of antibacterial drugs. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Table of Contents:
Introduction to Antimicrobial Therapeutics Reviews: The bacterial cell wall as an antimicrobial target v Karen Bush Recent trends in resistance to cell envelope active antibacterial agents among key bacterial pathogens 1 Ronald N. master, Jennifer Deane, Carol Opiela and Daniel F. Sahm The physiology of bacterial cell division 8 Alexander J. F. Egan and Waldemar Vollner Viable screening targets related to the bacterial cell wall 29 Lynn L. Silver Bacterial cell-wall recycling 54 Jarrod W. Johnson, Jed F. Fisher and Shahriar Mobashery -Lactam antimicrobials: what have you done for me lately? 76 George H. Talbot Proliferation and significance of clinically relevant -lactamases 84 Karen Bush Metallo- -lactamase structure and function 91 Timothy Palzkill New -lactam- -lactamase inhibitor combinations in clinical development 105 David M. Shlaes Siderophore conjugates 115 Malcolm G. P. Page Peptide antimicrobials: cell wall as a bacterial target 127 Nannette Y. Yount and Michael R. Yeaman Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall 139 Arnold S. Bayer, Tanja Schneider and Hans-Georg Sahl Errata for Ann. N. Y. Acad. Sci. Volumes 1274 and 1275 159


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Product Details
  • ISBN-13: 9781573318792
  • Publisher: New York Academy of Sciences
  • Publisher Imprint: New York Academy of Sciences
  • Height: 255 mm
  • No of Pages: 252
  • Spine Width: 8 mm
  • Width: 178 mm
  • ISBN-10: 1573318795
  • Publisher Date: 25 Feb 2013
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: The Bacterial Cell Wall as an Antimicrobial Target


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