Análise do marcador molecular FLT3 nas leucemias agudas na infância
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Análise do marcador molecular FLT3 nas leucemias agudas na infância

Análise do marcador molecular FLT3 nas leucemias agudas na infância


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About the Book

As neoplasias hematológicas compreendem um grande número de distúrbios cujas origens são atribuídas a alterações genéticas de células hematopoiéticas. Entre as neoplasias hematológicas, destacam-se as leucemias nas suas mais variadas formas. As leucemias correspondem a 30% dos casos de câncer em crianças, sendo as leucemias agudas responsáveis por 95% dos casos de leucemias infantis. Os receptores FLT3 são proteínas da família Tirosina Quinase que executam uma importante função na patogênese das leucemias agudas (94%), em particular da Leucemia Linfoblástica Aguda (LLA) de linhagem de células B, em 32% de linhagem de células T, em 89% das Leucemias Mielóides Agudas. A ativação constitutiva destes receptores ocorre em muitas leucemias em adultos e na infância. O objetivo deste trabalho foi identificar as mutações FLT3/ITD, FLT3/KD e a expressão absoluta do gene FLT3 nas leucemias agudas na infância em pacientes do Hospital Universitário Oswaldo Cruz - HUOC/PE, Recife.


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Product Details
  • ISBN-13: 9783639691146
  • Publisher: Novas Edicoes Academicas
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 3639691148
  • Publisher Date: 20 Feb 2015
  • Height: 229 mm
  • No of Pages: 64
  • Series Title: Portuguese
  • Weight: 154 gr


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