Approches récentes pour améliorer la solubilité des médicaments
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Approches récentes pour améliorer la solubilité des médicaments

Approches récentes pour améliorer la solubilité des médicaments


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About the Book

La solubilité est le phénomène de dissolution d'un solide dans une phase liquide afin d'obtenir un système homogène. La solubilité est l'un des paramètres importants pour atteindre la concentration souhaitée de médicament dans la circulation systémique afin que la réponse pharmacologique se manifeste. Il est généralement reconnu qu'une faible solubilité est l'une des difficultés les plus fréquemment rencontrées dans le domaine pharmaceutique. Une faible solubilité et une vitesse de dissolution insatisfaisante sont souvent des compromis avec la biodisponibilité orale des médicaments. Cet article présente les différentes techniques utilisées pour améliorer la solubilité aqueuse, ce qui peut constituer une aide précieuse pour accroître l'efficacité et réduire les effets secondaires des médicaments. Ainsi, plusieurs techniques sont utilisées pour améliorer la solubilité des médicaments peu solubles dans l'eau, notamment l'hydrotropie, l'ajustement du pH, la cosolvabilité, la solubilisation par miscellose, les techniques de fluides supercritiques, la dispersion solide, la complexation, la microémulsion, l'utilisation de surfectants et la nanonisation.


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Product Details
  • ISBN-13: 9786207721818
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 163 gr
  • ISBN-10: 6207721810
  • Publisher Date: 27 Jun 2024
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm


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Approches récentes pour améliorer la solubilité des médicaments
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