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Avaliação experimental do timol

Avaliação experimental do timol


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About the Book

O timol é um monoterpeno extraído do óleo essencial de diversas plantas aromáticas, sendo o componente principal do óleo essencial do alecrim-pimenta (Lippia sidoides). Este trabalho avaliou as ações comportamentais do timol em modelos animais de ansiedade, depressão, convulsão e sedação, tais como labirinto em cruz elevado (LCE), campo aberto, rota rod, nado forçado, suspensão da cauda, convulsão induzida por pentilenotetrazol e tempo de sono induzido por pentobarbital. Administrado por vo., em camundongos machos, em doses únicas de 25mg/Kg ou 50 mg/Kg. Não causou efeito relaxante muscular no teste do rota Rod nem alterou o número de cruzamentos no teste do campo aberto, mas reduziu o grooming. No LCE aumentou todos os parâmetros observados sugerindo um possível efeito ansiolítico. Não alterou a latência, mas aumentou a duração do sono. Aumentou a latência da convulsão na dose de 50mg/Kg, no entanto não foi capaz de alterar a latência de morte e a mortalidade dos animais. Apresentou efeito antidepressivo no teste do nado forçado e da suspensão da cauda. Este efeito foi revertido pelo pré-tratamento dos animais com antagonistas serotonérgicos, noradrenérgicos e dopaminérgicos.


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Product Details
  • ISBN-13: 9783639746693
  • Publisher: Novas Edicoes Academicas
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Spine Width: 7 mm
  • Weight: 240 gr
  • ISBN-10: 3639746694
  • Publisher Date: 26 Feb 2015
  • Height: 229 mm
  • No of Pages: 124
  • Series Title: Portuguese
  • Sub Title: ansiedade, depressão e convulsão
  • Width: 152 mm


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