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Bakterial'nye Poroformiruyushchie Toksiny

Bakterial'nye Poroformiruyushchie Toksiny


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About the Book

Toksiny, produtsiruemye bakteriyami, igrayut osnovnuyu rol' v razvitie zabolevaniy. Odin iz toksinov Bacillus cereus - gemolizin II(HlyII) naibolee interesen, tak kak ego gen obnaruzhen ne tol'ko v B.cereus, kotoryy mozhet vyzyvat' diarreynyy i emeticheskiy sindromy, zabolevaniya glaz, mastity, meningit, no i v B.thuringiensis, ispol'zuyushchimsya dlya proizvodstva insektitsidnykh preparatov, i v B.anthracis vyzyvayushchego sibirskuyu yazvu. HlyII yavlyaetsya poroobrazuyushchim tsitoliticheskim toksinom, kotoryy sekretiruetsya bakteriyami v okruzhayushchuyu sredu v forme monomera. Monomery HlyII vzaimodeystvuyut s kletochnymi membranami, oligomerizuyutsya s obrazovaniem otkrytykh transmembrannykh geksa-, gepta- i oktamernykh struktur- nanopor s funktsional'nym diametrom 12-16Å. Nizkomolekulyarnye veshchestva nachinayut prokhodit' cherez nanopory, chto privodit k narusheniyu gomeostaza i k gibeli kletki. HlyII liziruet razlichnye eukarioticheskie kletki i mozhet privodit' k gibeli makroorganizma, naprimer dafniy- pri etom proiskhodit lizis mnozhestva kletok, chto privodit k narusheniyu atakuemykh organov. Tsitoliticheskoe patogennoe deystvie HlyII na raznye kletki i makroorganizmy obuslovleno obrazovaniem ionprovodyashchikh kanalov v kletochnykh membranakh.


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Product Details
  • ISBN-13: 9783843301176
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: Russian
  • Returnable: N
  • Spine Width: 10 mm
  • Width: 152 mm
  • ISBN-10: 3843301174
  • Publisher Date: 26 Oct 2010
  • Height: 229 mm
  • No of Pages: 164
  • Series Title: Russian
  • Weight: 299 gr


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Bakterial'nye Poroformiruyushchie Toksiny
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Bakterial'nye Poroformiruyushchie Toksiny
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