Benzodiazepines II: A Handbook. Basic Data, Analytical Methods, Pharmacokinetics, and Comprehensive Literature

" ... this is an excellent compilation of data which should be on the bookshelves of all analysts interested in the benzodiazepines. It is to be hoped that, with the introduction of so many new ben­ zodiazepines, the author will quickly add these in a second edi­ tion" (A. C. Moffat in: Trends in Analytical Chemistry, 1983). This review, deputizing for many others, reflects the friendly reception enjoyed by the first volume of Benzodiazepines, which was published in 1982 and apparently closed a gap in the ben­ zodiazepine literature. In the meantime, Benzodiazepines has established itself as a standard book, as evidenced by numerous letters and quotations. Suggestions were also soon made for a new edition in view of the unusually rapid development in the field of the benzodiazepines. It became quickly obvious, however, that it would not be sufficient to publish a revised second edition, but that a completely new second volume would be required for which, however, the successful previous format could be largely retained. The following considerations seem worth mentioning in connection with the preparation of Volume II: - To ensure continuity with Volume I as far as possible, the list of references was consecutively numbered (references 1 to 3779 in Volume I, references 3780 to 11338 in Volume II). Whereas in Vol. I the substances appear in the sequential order of their historical development they are listed in alphabetical order in Vol. II.

Table of Contents:
Index of Treated Substances.- List of Synonyma.- Biotransformation.- Formation of the Hydrolysis Derivatives.- TLC-Data.- Thin-Layer Chromatography — The Concept of the Corrected Rf-Value (Rfc-Value).- Screening of the Benzodiazepines via Rfc-Values.- Screening of the Benzodiazepines via Aminobenzophenones and Bratton-Marshall Detection.- GLC-Data and UV-Spectra.- Gas Chromatography — The Concept of the Retention Index.- List of UV-Maxima.- UV-Spectra (Ultraviolet-Spectra).- List of Important m/z-Values.- Infrared- and Mass-Spectra.- Immunological Methods.- Presentation of Analytical Methods.- Methods for the Determination of New Benzodiazepines.- Additional Methods for the Determination of Benzodiazepines Already Described in Vol. I.- List of Therapeutic and Toxic Concentrations.- Blood-, Serum- and Plasma-Levels and Other Pharmacokinetic Data from Literature.- alprazolam.- brotizolam.- clotiazepam.- delorazepam, chlordesmethyldiazepam.- estazolam.- ethyl loflazepate.- flumazenil, Ro 15–1788.- halazepam.- loprazolam.- metaclazepam.- midazolam.- oxazolam.- pinazepam.- quazepam.- temazepam.- tetrazepam.- triazolam.- Survey of Benzodiazepine Literature.- 1 Absorption Studies.- 2 Analytical Studies.- 3 Antagonist Studies.- 4 Anesthesia Studies.- 5 Behavioral Studies.- 6 Biotransformation/Metabolism.- 7 Casuistics.- 8 Feto-Maternal-Studies.- 9 GABA-Studies.- 10 Galenic Studies.- 11 Gas-Chromatography.- 12 High-Pressure-Liquid-Chromatography.- 13 Hydrolysis Studies.- 14 Immunoassays (RIA, EMIT, TDx and Others).- 15 Interactions.- 16 Mass-Spectrometry.- 17 NMR-Studies.- 18 Pharmacokinetics (Levels).- 19 Pharmacology and Clinical Studies.- 20 Photometry (UV-, IR-, VIS-, Fluorometry).- 21 Polarography.- 22 Protein Binding.- 23 Radioactive-Labelled Compounds.- 24Radioreceptor Assays.- 25 Receptor Studies.- 26 Review Articles.- 27 Screening Methods.- 28 Side-, Adverse-, Residual-Effects.- 29 Sleep Studies.- 30 Synthesis of Benzodiazepines.- 31 TLC-Studies.- 32 Toxicity.- 33 Miscellaneous.- References.