Biologically Responsive Biomaterials for Tissue Engineering

Preface

Chapter 1 Scaffold Design For Bone Tissue Engineering: From Micrometric To Nanometric Level
1.1 Introduction
1.2 Scaffold Design: basic criteria
1.3 Designing microstructure
1.3.1 Hierarchically organized architecture
1.3.2 Multi-scale degradation
1.4 Surface and bulk bioactivation
1.5 Designing nanostructures
1.5.1 Micro or nanotexture?
1.5.2 Chemical cues for cell recognition
1.6 Conclusion
1.7 References

Chapter 2 Molecular Scissors - from Biomaterials Implant to Tissue Remodeling
2.1 Introduction
2.2 Extracellular matrix tailoring by specific means
2.3 Proteases and MMPs family
2.4 MMPs activity depends on catalytic domain structure and behavior
2.5 MMPs natural inhibitors
2.6 MMPs in wound repair
2.7 MMPs in epithelial repair
2.8 MMP involvement in resolution step of wound healing
2.9 TIMPs in wound repair
2.10 Evaluation of immunohistochemical detection of MMPs in periimplant tissues
2.11 Summary
2.12 References

Chapter 3 Synthetic Morphogens and Pro-morphogens for Aided Tissue Regeneration
3.1 Introduction: morphogen definition
3.2 Morphogens in vertebrates
3.3 Morphogen long-distance transport and local mechanisms
3.4 Growth factors as morphogens
3.5 Knowledge in developmental biology: lessons for therapeutically-driven tissue regeneration
3.6 Growth factors in adult tissue repair and regeneration
3.6.1 Use of growth factors in clinical intervention
3.6.2 Limitation in the use of growth factors in clinical intervention
3.7 Synthetic morphogens, growth factors and bioligands
3.7.1 Identification of bioactive sequences by phage displayed peptide technique
3.8 Current limitations and future strategies to improve the therapeutic potential of analogue morphogens, growth factors and bioligands
3.8.1 Current limitations
3.8.2 Future strategies
3.9 Conclusions
3.10 References

Chapter 4 The role of oxidative stress in the response of endothelial cells to metals
4.1 Metallic materials for implantation
4.2 Aseptic loosening and metal corrosion
4.3 Integration of metal implants and the role of endothelial cells
4.4 Oxidative stress: ROS formation and antioxidant defence mechanisms
4.5 Ti6Al4V-induced oxidative stress
4.6 Cathodic half-reaction of corrosion as the possible source of oxidative stress on Ti6Al4V alloy
4.7 Summary
4.8 References

Chapter 5 Comparative properties of ethyl, n-butyl and n-octyl cyanoacrylate bioadhesives intended for wound closure
5.1 Introduction
5.2 Experimental
5.2.1 Materials
5.2.2 Experimental techniques
5.3 Results and discussion
5.4 Conclusions
5.5 References

Chapter 6 Development of bioabsorbable interference screws - how influence biomaterials composition, clinical and retrieval studies the innovative screw design and manufacturing processes
6.1. Introduction
6.2. Interference screws classification and design
6.3. New design for a bioresorbable interference screw
6.3.1 Clinical and retrieval study
6.3.2. Innovative design of a bioresorbable interference screw
6.3.3 Discussion about the functionality of the new design for bioresorbable interference screw
6.4. Biodegradable interference screws manufacturing processes
6.5 Conclusions
6.6. References

Chapter 7 Modeling And Numerical Analysis Of A Cervical Spine Unit
7.1 Introduction
7.2 Solid Reconstruction Modeling of a Cervical Vertebra
7.2.1 Image Acquisition
7.2.2 Image Processing
7.2.3 Surface Generation
7.2.4 Solid Generation
7.3 Classical Geometric Modeling of a Functional Implanted Unit C2-C3
7.4 Simulation of Mechanical Behavior for Implanted Cervical Unit
7.4.1 FEA Main Stages
7.4.2 Mechanical Effects at the Bone - Screw Interfaces
7.5 Conclusions
7.6 References

Chapter 8 Carbon Nanotubes in Acrylic Bone Cement
8.1 The Hip Joint
8.1.1 Potential Pr