Preface, Romesh Khardori; Section I Histamine biology and physiology: 1 An overview of histamine synthesis, regulation and metabolism, and its clinical aspects in biological system: Mohd. Shahid, Trivendra Tripathi, Nancy Khardori, Rahat Ali Khan; 2 Regulation of mammalian histamine synthesis: histidine decarboxylase: Satoshi Tanaka, Atsushi Ichikawa; Section II Enzymology in histamine biology: 3: Enzymology in histamine biogenesis: Almudena PINO-ÁNGELES, Aurelio A. MOYA-GARCÍA, Miguel Ángel MEDINA, Francisca SÁNCHEZ-JIMÉNEZ; Section III Pharmacology of histamine noble receptors and their ligands in drug development: 4: Biological and pharmacological aspects of histamine receptors and their ligands: Mohd. Shahid, Trivendra Tripathi, Rahat Ali Khan, Nancy Khardori, Ali Ibrahim Al-Sultan, Hamdan Ibrahim AL-Mohammed, Abdulrahman A. Alsultan, Anwar Huq, Aijaz Ahmed Khan, Mashiatullah Siddiqui; Section IV Histamine role in immune modulation & regulation: 5 The role of histamine in immunoregulation in context of T-regulatory and invariant NKT cells: Varun Dwivedi, Renukaradhya J. Gourapura; 6 Immune regulation by various facets of histamine in immunomodulation and allergic disorders: Trivendra Tripathi, Mohd. Shahid, Farrukh Sobia, Anuradha Singh, Haris M. Khan, Rahat Ali Khan, Mashiatullah Siddiqui; Section V Histamine in regulation of cell proliferation and differentiation: 7 Effects of histamine on T lymphocytes: Manzoor M. Khan; 8 Histamine aspects in acid peptic diseases and cell proliferation: Jameel Ahmad, Monika Misra, Waseem Rizvi, Anil Kumar; Section VI Histamine role in pathogenesis & diagnosis of allergic, inflammatory, autoimmune and cancer diseases: 9 Histamine: Role in pathogenesis of autoimmune, allergic, inflammatory and malignant diseases: Trivendra Tripathi, Mohd. Shahid, Haris M. Khan, Mashiatullah Siddiqui, Aijaz Ahmed Khan, Rahat Ali Khan; 10 Biological characteristics of histamine receptors in airways disease management: Rajni Kant Shukla, Priyanka Jain, Sandeep Bhattacharya; Section VII Histamine role in inflammation and allergy: 11 Mast cells as a source and target for histamine: Ewa Brzezińska-Blaszczyk; 12 Histamine H1 receptor gene expression mechanism as a novel therapeutic target of allergy: Hiroyuki Fukui, Hiroyuki Mizuguchi; Section VIII Histamine in the nervous system: 13 The neuronal histamine and it's receptors as new therapeutic targets for food intake and obesity: Takayuki Masaki; 14 Implications of histaminergic system in brain histamine dysfunction: Aijaz Ahmed Khan, Trivendra Tripathi, Mohd. Shahid, Haris M. Khan, Rahat Ali Khan; Section IX Histamine H3 receptor: A target for momentous brain research: 15 Pre-synaptic control by histamine H3-receptors of neurotransmitter release: Angélica Osorio-Espinoza, Judith Ramos-Jiménez, José-Antonio Arias-Montaño; Section X Histamine H4 receptor: A noble target for inflammatory and immune research: 16 Expression of histamine H4-receptor in human synovial cells and dermal tissues: Yoshiko Matsuda, Katsunori Yamaura, Masahiko Suzuki, Takao Namiki, Koichi Ueno; Section XI Role of histamine in reproductive function: 17 Novel role for histamine through classical H1 and H2 receptors: regulation of leydig cell steroidogenesis and its implications for male reproductive function: Carolina Mondillo, Omar Pignataro; 18 Possible effect of histamine in physiology of female reproductive function: An updated review: Nasreen Noor, Trivendra Tripathi, Shagufta Moin, Abdul Faiz Faizy; Section XI Other biomedical aspects of histamine agonists, antagonists, and inverse agonists: 19 Histamine role in malaria: Adil Raza, Haris M. Khan, Fatima Shujatullah; 20 Histamine-cytokine and histamine-antibody network in immune regulation: Trivendra Tripathi, Richa Pandey, Haris M. Khan, Mohd. Shahid, Adil Raza, Mashiatullah Siddiqui, Rahat Ali Khan; Index