Editorial.- Contributors.- 1 Brain aging: a critical reappraisal, Mahendra K Thakur, Arpita Konar, Akash Gautam .- 2 Base excision DNA repair: the house keeping guardian for genomic stability in the brain, Umakanta Swain, Kalluri Subba Rao.- 3 Role of brain-derived neurotrophic factor as a modulator of synaptic plasticity, Yasuyuki Ishikawa, Masami Kojima. 4 Mitochondrial dysfunction in sporadic Alzheimer's disease: mechanisms, consequences and interventions, Sasanka Chakrabarti, Maitrayee Sinha.- 5 Brain Aging: Influence of early-life events on late-life brain disorders, Debomoy K Lahiri.- 6 The importance of the environment in brain aging: Be happy, live longer, Mónica De la Fuente, Lorena Arranz.- 7 Consequences of altered mortalin expression in control of cell proliferation and brain function, Renu Wadhwa, Sunil C Kaul.- 8 Age induced alterations in biological clock: Therapeutic effects of melatonin changes in regulation of biological clock, Anita Jagota.- 9 Neurolipofuscin in aging and aluminum-induced aging: Possible therapeutic interventions, Mahdi Hasan, Sandeep Tripathi, Abbas A Mahdi.- 10 Dietary restriction as a potential intervention to retard age-associated impairment of brain functions, Gurcharan Kaur, Sukhwinder S Lakhman.- 11 Understanding mechanism of action of herbal drugs in age-related degenerative brain disorders, Maheep Bhatnagar, Ayushi Jain, Neha Jaiswal, Chavi Sharma, Pooja Suvalka.- 12 Neurodegeneration in hypoxia: implications in aging, Kalpana Barhwal Hota, Sunil Kumar Hota, Shashi Bala Singh.- 13 Stress and memory; from mechanisms to long-lasting consequences, Harmen J Krugers, Marian Joels.- 14 Estrogen mediated neuroprotection: Hope to combat neuronal degeneration and synaptic plasticity post-menopause, Raj D Mehra, Mukesh K Varshney, Pavan Kumar.- 15 Potential therapeutic targets for memory impairments and dementia: Clues obtained from memory-enhanced mice, Shogo Endo.- 16 Potential beneficial effects of a diet with walnuts in aging and Alzheimer's disease, Abha Chauhan, Ved Chauhan.- 17 Smart dietary interventions and prevention of cognitive decline with aging, S Asha Devi.- 18 Herbal cognitive enhancers: New developments and challenges for therapeutic applications, Andrea Zangara, Keith A Wesnes.- Index