Cambiamenti neurofunzionali perinatali indotti dalla fluoxetina
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Cambiamenti neurofunzionali perinatali indotti dalla fluoxetina

Cambiamenti neurofunzionali perinatali indotti dalla fluoxetina


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International Edition


About the Book

Esiste un rischio considerevole di sviluppare la depressione durante la gravidanza e l'allattamento. Il trattamento farmacologico della depressione nelle donne in gravidanza è consigliato in molti casi e i farmaci di scelta sono gli inibitori della ricaptazione della serotonina (SSRI), come la fluoxetina. Considerando che la serotonina modula diversi processi durante lo sviluppo dell'organismo, si stanno studiando i potenziali effetti dell'esposizione perinatale agli SSRI sul neurosviluppo. Nei ratti, l'esposizione alla fluoxetina durante il periodo perinatale (gravidanza e allattamento) ha ridotto la capacità decisionale, ma non ha indotto anedonia, nei maschi e nelle femmine adolescenti. In risposta a un fattore di stress, non vi era alcuna differenza nella secrezione di corticosterone, ma i maschi adolescenti presentavano una ridotta attivazione dell'amigdala basolaterale e in età adulta questa riduzione si verificava nell'amigdala mediale. Questo studio indica che l'esposizione perinatale alla fluoxetina induce alterazioni neurofunzionali che possono dipendere dal sesso e dall'età, evidenziando l'importanza dell'ambiente perinatale come determinante delle alterazioni neurofunzionali che proseguono in età adulta.


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Product Details
  • ISBN-13: 9786207212385
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 620721238X
  • Publisher Date: 27 Feb 2024
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 150 gr


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