Part I: Background: Epigenetic Mechanism
1. Cancer Epigenetics: An Introduction
Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta
2. Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program
John S. Satterlee, Andrea Beckel-Mitchener, Kim McAllister, Dena C. Procaccini, Joni L. Rutter, Frederick L. Tyson, and Lisa Helbling Chadwick
3. Epigenome-Wide Association Studies (EWAS): Past, Present, and Future
James M. Flanagan
4. Epigenetic Biomarkers in Liver Cancer
Krishna K. Banaudha and Mukesh Verma
Part II: Cancer Specific Type Epigenetic Changes
5. Cancer Type Specific Epigenetic Changes: Gastric Cancer
Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano
6. Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer
Andrea J. Savio and Bharati Bapat
7. Prostate Cancer Epigenome
Swathi Chinaranagari, Pankaj Sharma, Nathan J. Bowen, and Jaideep Chaudhary
8. CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer
Yujin Kim and Duk-Hwan Kim
9. Analysis of DNA Methylation in Pancreatic Cancer: An Update
Christian Pilarsky and Robert Grützmann
10. Epigenetics of Urothelial Carcinoma
Wolfgang A. Schulz, Evangelia A. Koutsogiannouli, Günter Niegisch, and Michèle J. Hoffmann
11. Epigenetics of Prostate Cancer
Tawnya C. McKee and James V. Tricoli
12. Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options
Xinbo Zhang, Naimei Tang, Arun K. Rishi, Harvey I. Pass, and Anil Wali
Part III: Methods and Technologies Used for Detecting Epigenetic Changes
13. Techniques to Access Histone Modifications and Variants in Cancer
Monica Tyagi, Shafqat A Khan, Saikat Bhattacharya, Divya Reddy, Ajit K Sharma, Bharat Khade, and Sanjay Gupta
14. Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS
Maria A. Hahn, Arthur X. Li, Xiwei Wu, and Gerd P. Pfeifer
15. Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer
Atsushi Kaneda and Koichi Yagi
16. Histone Modifications Associated with Cancer Cell Migration and Invasion
Miki Hieda, Nariaki Matsuura, and Hiroshi Kimura
Part IV: Factors that Influence Epigenetic Changes in Cancer
17. Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers
Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan
18. Cancer-Associated Infectious Agents and Epigenetic Regulation
Vidya Vedham and Mukesh Verma
19. Toxicoepigenomics and Cancer: Implications for Screening
Mukesh Verma
20. Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome
Josena K. Stephen and Maria J. Worsham
21. Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies
Mukesh Verma
22. Epigenetics of Colorectal Cancer
Wenji Yan and Mingzhou Guo
23. Epigenetics in Breast and Prostate Cancer
Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama
Part V: Future Directions: Risk Assessment, Diagnosis, Treatment, and Prognosis
24. Epigenetic Inhibitors
Mukesh Verma and Hirendra Nath Banerjee
25. Use of Epigenetic Modulators as a Powerful Adjuva
