Cancer Genome and Tumor Microenvironment by Andrei Thomas-Tikhonenko
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Cancer Genome and Tumor Microenvironment

Cancer Genome and Tumor Microenvironment


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Part One: Opening remarks Hardwiring tumor progression (Andrei Thomas-Tikhonenko) Part Two: Breaking away: Epithelial-mesenchymal transition PI3K/AKT pathway and the epithelial-mesenchymal transition (Alfonso Bellacosa and Lionel Larue) Loss of cadherin-catenin adhesion system in invasive cancer cells (Wen-Hui Lien and Valeri Vasioukhin) Rho GTPases in regulation of cancer cell motility, invasion, and microenvironment (Donita Brady, Jamie Alan, and Adrienne Cox) Merlin/NF2 tumor suppressor and Ezrin-Radixin-Moesin (ERM) proteins in cancer development and progression (Ling Ren and Chand Khanna) Part Three: Coming up for air: Hypoxia and Angiogenesis von Hippel-Lindau tumor suppressor, hypoxia-induced factor-1, and tumor vascularization (Huafeng Zhang and Gregg Semenza) RAS oncogenes and tumor-vascular interface (Janusz Rak) Myc and control of tumor neovascularization (Prema Sundaram, Chi V. Dang, and Andrei Thomas-Tikhonenko) p53 and angiogenesis (Jose Teodoro, Sara Evans, and Michael Green) Ink4a locus: beyond cell cycle (Gregory Enders) Part Four: Gaining new ground: Metastasis and stromal cell interactions NM23 as a metastasis inhibitor (Rajeev Kaul, Masanao Murakami, Pankaj Kumar, and Erle Robertson) HGF/c-MET signaling in advanced cancers (Mandira Ray, JG Garcia, and Ravi Salgia) Contribution of ADAMs and ADAMTSs to tumor expansion and metastasis (Antoni Xavier Torres-Collado and Luisa Iruela-Arispe) Stromal cells & tumor milieu: PDGF et al (Michele Jacob and Ellen Puré) Tgf-beta signaling alterations in neoplastic and stromal cells (Qinghua Zeng and Boris Pasche) Part Five: Getting attention: Immunerecognition and inflammation Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers (Antonia Sepulveda and John Lynch) Immunoglobulin gene rearrangements, oncogenic translocations, B-cell receptor signaling, and B-lymphomagenesis (Murali Gururajan and Subbarao Bondada) Modulation of Philadelphia chromosome-positive hematological malignancies by bone marrow microenvironment (Lin Wang, Heather O'Leary, and Laura Gibson) Part 6: Putting it all together Melanoma: mutations in multiple pathways at the tumor-stroma interface (Himabindu Gaddipati and Meenhard Herlyn) Cooperation and Cancer (Kathleen Sprouffske and Carlo Maley, Wistar Institute)


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Product Details
  • ISBN-13: 9781461425243
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2010 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 26 mm
  • Width: 156 mm
  • ISBN-10: 1461425247
  • Publisher Date: 07 Mar 2012
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 480
  • Series Title: Cancer Genetics
  • Weight: 761 gr


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