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Caractérisation et purification de molécules cages

Caractérisation et purification de molécules cages


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About the Book

L'imagerie médicale (IRM) est devenue un outil indispensable au diagnostic d'un grand nombre de pathologies. De nouvelles méthodes utilisant des gaz nobles hyperpolarisés (129Xe, 3He) ont été développées et ont prouvé leur efficacité pour augmenter la sensibilité de l'IRM. Grâce à son caractère hydrophobe, le xénon hyperpolarisé peut être encapsulé et transporté dans des molécules cages destinées à cibler des récepteurs biologiques. Plusieurs de ces molécules ont été synthétisées au laboratoire puis fonctionnalisées afin d'obtenir des biosondes hydrosolubles. Ce livre porte sur le développement et l'optimisation de méthodes séparatives utilisant des techniques couplées (LC-MS-UV-DEDL) pour caractériser, purifier et quantifier deux catégories de molécules cages: les cucurbiturils et les cryptophanes. A l'issue de ces purifications ces molécules ont fait l'objet d'études in vitro en RMN-129Xe confirmant la grande potentialité de cette approche.


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Product Details
  • ISBN-13: 9783841679604
  • Publisher: Editions Universitaires Europeennes
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 10 mm
  • Width: 152 mm
  • ISBN-10: 3841679609
  • Publisher Date: 24 Nov 2015
  • Height: 229 mm
  • No of Pages: 180
  • Series Title: French
  • Weight: 322 gr


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Caractérisation et purification de molécules cages
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Caractérisation et purification de molécules cages
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