Preface
Section I History and origins
Chapter 1: Origins of the Hayflick system, the phenomenon and the limit. (an interview by Suresh I.S. Rattan)
Chapter 2: Experimental foundations of the Hayflick system. (an interview by Suresh I.S. Rattan)
Section II Serial passaging and progressive changes
Chapter 3: Slowing down of the cell cycle during fibroblast proliferation. by: Alvaro Macieira-Coelho
Chapter 4: Influence of donor age and species longevity on replicative cellular senescence. by: Lorenzini and Andrea B. Maier
Chapter 5: Ageing of the stem cells: the conjoined twosome growing old -stem cell and its niche. by: Günter Lepperdinger
Chapter 6: Ageing and senescence in immune cells in vitro and in vivo. by: Graham Pawelec and Yvonne Barnett
Chapter 7: Telomere shortening - a mere replicometer? by: Stella Victorelli and Joao Passos
Chapter 8: Modelling cellular ageing: mathematical and computational approaches. by: Tarynn M. Witten
Section III AGEING, CANCER and sen
escence
Chapter 9: Cell cycle checkpoints and senescence. by: Renu Wadhwa, Zeenia Kaul and Sunil C. Kaul Chapter 10: Mitochondrial reactive oxygen species in cellular senescence. by: Timothy Nacarelli, Claudio Torres and Christian Sell
Chapter 11: Cellular aging and tumour regulation. by: Andreas Simm, Barbara Seliger and Lars-Oliver Klotz
Chapter 12:
Biomarkers of replicative senescence revisited. by: Jan Nehlin Section IV AGEING ModulatORS
Chapter 13: Stress-induced (premature) senescence. by: Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire and Olivier Toussaint
Chapter 14: Implications of cellular senescence on aging and disease in the brain. by:
Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D'Agostino, Christian Sell and Claudio Torres Chapter 15: Small non coding RNAs in senescence and aging. by: Joseph Dhahbi Chapter 16: Targeting senescent cells to improve huan health by: Tobias Wijshake and Jan M. A. van Deursen
Section V RECAPITULATION AND FUTURE EXPECTATIONS
Chapter 17: Unlike the stochastic events that determine ageing, sex determines longevity. by: Leonard Hayflick
Index
