Characterization of Interleukin-33 and the IL-33 Receptor Complex
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Characterization of Interleukin-33 and the IL-33 Receptor Complex

Characterization of Interleukin-33 and the IL-33 Receptor Complex


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About the Book

Two pivotal aspects of the IL-33 system are characterized in this study: First the composition and function of the IL-33 receptor complex on IL-33 responder cells and second the generation of biologically active IL-33 by the IL-33 producer cell. IL-33 binds to the IL-33 receptor α-chain (ST2) and as is shown here, this results in the recruitment of interleukin-1 receptor accessory protein (IL-1RAcP) as the co-receptor. The IL-33-dependent interaction of membrane bound and soluble form of IL-1RAcP and IL-33Rα-chain was demonstrated in co-immunoprecipitation assays. Common notion in the field is that IL-33, like IL-1β and IL-18, requires processing by caspase-1 to a mature form, in order to achieve biological activity as a cytokine. Contrary to the current dogma, here it is described that IL-33 is biologically active as unprocessesed full length molecule. Full length IL-33 binds to the IL-33 receptor-α chain and mediates the recruitment of IL-1RAcP to activate cells. IL-33 is processed in cells, however not by caspase 1 to a mature, biologically active, IL-33 but instead it is cleaved by caspase 3 at aa175 to yield two products which are both unable to bind to the IL-33 receptor.


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Product Details
  • ISBN-13: 9783639148183
  • Publisher: VDM Verlag
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 8 mm
  • Width: 152 mm
  • ISBN-10: 3639148185
  • Publisher Date: 23 Apr 2010
  • Height: 229 mm
  • No of Pages: 136
  • Series Title: English
  • Weight: 258 gr


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Characterization of Interleukin-33 and the IL-33 Receptor Complex
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