Chemische Und Biochemische Methoden Zum Aufbau Bioaktiver Stickstoff-Heterozyklen
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Chemische Und Biochemische Methoden Zum Aufbau Bioaktiver Stickstoff-Heterozyklen

Chemische Und Biochemische Methoden Zum Aufbau Bioaktiver Stickstoff-Heterozyklen


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About the Book

Bei der Gewinnung biologisch aktiver Naturstoffe stehen zwei grundlegend verschiedene Vorgehensweisen zur Verfugung. Die klassische Naturstoffsynthese bietet eine gute Moglichkeit, Substanzen in ausreichender Menge zu erhalten und Strukturanaloga zu generieren. Eine Alternative bietet die direkte Isolierung der gewunschten Verbindung aus dem produzierenden Organismus. Hierfur ist die Aufklarung der jeweiligen Biosynthese von grosser Bedeutung. In der vorliegenden Arbeit wurde einerseits die Synthese stickstoffhaltiger Heterozyklen untersucht, wahrend andererseits im zweiten Teil der Arbeit Untersuchungen zur Aufklarung der Biosynthese stickstoffhaltiger Verbindungen durchgefuhrt wurden. Die Zielmolekule der Naturstoffsynthese waren die 2004 entdeckten Rostratine, Mykotoxine mit Diketopiperazingrundgerust, die ausserst interessante biologische Eigenschaften aufweisen. In der vorliegenden Arbeit wurde eine effiziente Methode zur Dimerisierung funktionalisierter zyklischer Aminosauren entwickelt, die fur die Synthese vieler Diketopiperazine eingesetzt werden kann. Des Weiteren konnte mittels einer intramolekularen Diels-Alder-Reaktion ein Zugang zu substituierten Hexahydroindolen entwickelt werden, die fur die Totalsynthese der Rostratine essentiell sind. Der Naturstoffsynthese steht die Gewinnung biologisch aktiver Substanzen durch Fermentation gegenuber. Die Monoterpenindolalkaloide stellen eine wertvolle Substanzklasse dar, deren Biosynthese genauer untersucht werden sollte. Zunachst wurde ein Inhibitor fur das Schlusselenzym Strictosidin-Synthase synthetisiert, der fur Cokristallstudien verwendet werden konnte. Zudem konnten erstmalig Tryptaminazide synthetisiert werden, die zur Photoaffinitatsmarkierung biosynthetischer Enzyme in Catharanthus roseus verwendet werden sollten und somit deren Identifizierung moglich macht.


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Product Details
  • ISBN-13: 9783832518400
  • Publisher: Logos Verlag Berlin
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 0 mm
  • Width: 145 mm
  • ISBN-10: 3832518401
  • Publisher Date: 21 Feb 2008
  • Height: 210 mm
  • No of Pages: 166
  • Series Title: Beitrage Zur Organischen Synthese
  • Weight: 750 gr


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