Conceção e desenvolvimento da administração de fármacos auto-microemulsionados com nitrendipina
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Conceção e desenvolvimento da administração de fármacos auto-microemulsionados com nitrendipina

Conceção e desenvolvimento da administração de fármacos auto-microemulsionados com nitrendipina


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About the Book

O sistema auto-microemulsionante de administração de fármacos (SMEDDS) de Nitrendipina teve como objetivo ultrapassar os problemas de fraca solubilidade e biodisponibilidade. A estratégia de formulação incluiu a seleção da fase oleosa com base em estudos de solubilidade saturada e a seleção de surfactantes e co-surfactantes com base na sua capacidade de emulsificação. Foram construídos diagramas de fase ternários para identificar a região auto-emulsionante. Concluiu-se que o oleato de etilo como óleo, o Cremophore RH40 como tensioativo e o PEG 400 como co-surfactante eram componentes optimizados. O SMEDDS preparado foi caracterizado através do tamanho das gotículas, do potencial zeta, do tempo de auto-emulsificação e da determinação do teor de fármaco. A formulação optimizada apresentou uma libertação de fármaco in vitro de 98%, que foi significativamente superior à da solução de fármaco. Os estudos de espetroscopia de infravermelhos, calorimetria diferencial de varrimento, SEM e difração de raios X não indicaram qualquer incompatibilidade entre o fármaco, o óleo e os tensioactivos. A partir dos estudos de estabilidade do SMEDDS sólido, não se verificou uma diminuição significativa da libertação do fármaco e do teor de fármaco, pelo que a formulação é considerada estável e, em seguida, o estudo comparativo da libertação in vitro do lote optimizado.


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Product Details
  • ISBN-13: 9786206996613
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 145 gr
  • ISBN-10: 6206996611
  • Publisher Date: 28 Dec 2023
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm


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