Coronary Circulation: Anatomy, Mechanical Properties, and Biomechanics
Preface
Overview, Scope, Goal of Book, Acknowledgments
Chapter 1: Biomechanics
1.1 Introduction
1.2 Basic Terminology in Biomechanics
Stress,
Strain
Compliance, Stiffness, Distensibility, and Young's Modulus,
Viscoelasticity
1.3 Approach
1.4 Structure and Geometry
1.5 Material Properties
1.6 Laws of Mechanics
1.7 Boundary Conditions
1.8 Boundary Value Problems
1.9 Solution of Boundary Value Problems
Computational Fluid Dynamics
Finite Element Method, Fluid-Structure Interaction
ALE Formulation for Fluid-Structure-Interaction
Immersed Boundary (IB) Method
Chapter 2: Morphometry of Coronary Vasculature
2.1 Introduction
2. 2 Coronary Vasculature
2.3 Reduction of Coronary Vasculature
Casting Material
Animal and Isolated Heart Preparation
Polymer Cast of Coronary Vasculature
Histological and Cast Specimens
Morphometric Measurements
Diameter-Defined Strahler System
Meshing of Histological and Cast Data
Segments and Elements
Connectivity Matrix
Longitudinal Position Matrix
Asymmetry Ratios
Counting Total Number of Elements
Arcade-Like Vessels: Epicardial Veins
Network-Like Vessels: Capillaries
Diameters and Lengths of Capillary Segments
Topology of Arteriolar and Venular Zones and Mean Functional Capillary Length
2. 4 Integration of 3D Coronary Vasculature
Node to Node Computer Reconstruction of Coronary Network
Anatomical Input Files
Statistical 3D Reconstruction of Coronary Vasculature
Existing database and Additional Assumptions
Reconstruction Approach
Geometric Optimization
Verification of Coronary Network
2.5 Non-Tree Structures
2.6 Labor Savings in Morphological Reconstruction
2.7 Automation: Segmentation and Centerline Detection
Image Processing
Segmentation of Vessel Boundary
Segmentation under Topological Control
Centerline Detection
Vector Field
Determination of the Centerlines
Geometric Reconstruction
2.8 Grid Generation
Element Quality
2.9 Visualization of Reconstructed Network
2.10 Patient Specific Coronary Morphometry
Chapter 3: Mechanical Properties and Microstructure of the Coronary Vasculature
3.1 Introduction
3.2 Compliance, Distensibility, and Stiffness
Epicardial Arteries
Capillaries
3.3 Effect of Surrounding Tissue: Radial Constraint and Tethering
Pressure-Cross Sectional Area Relation
Pressure-Volume Relation
Slackness between Vessels and Myocardium
3.4 Zero-Stress State
Circumferential Residual Strain
Longitudinal Distribution of Mean Stress and Strain
Transmural Wall Strain Distribution
Effect of No-Load Duration on Opening A
About the Author:
Dr. Kassab received his BS (Chemical Engineering), MS (Engineering Sciences), and PhD (Bioengineering, Summa Cum Laude) from UCSD. He previously served as the Guidant Chair and Professor at Indiana/Purdue University. He is the founder and current President of California Medical Innovations Institute in San Diego.Dr. Kassab is the recipient of the NIH Young Investigator Award, AHA Established Investigator Award, Farriborz Maseeh Best Research Award, Abraham M. Max Distinguished Professor Award, Eminent Engineer Award of Tau Beta Pi Engineering Honor Society, Indiana's President Circle Award, and Glenn IrwinChancellor Best Research Scholar Award. Dr. Kassab has published over 300full-length publications and his scientific interests encompass the biomechanics of cardiovascular and gastroenterology systems in health and disease. He also has over 250 issued or pending patents in the areas of diagnosis and treatment of heart disease, aneurysm, and obesity. Dr. Kassab's intellectual properties have resulted in multiple start-ups and licensesto the medical device industry.
