Costruire il ginocchio bionico Book by Stefani Meyer
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Costruire il ginocchio bionico

Costruire il ginocchio bionico


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About the Book

La cartilagine è un tessuto connettivo parte integrante del funzionamento delle articolazioni. Un passo promettente nel trattamento della cartilagine difettosa è l'impianto di cellule staminali del midollo osseo autologo nel sito del difetto. Quando sono trasportate da un'impalcatura appropriata per fornire segnali condrogenici, le cellule staminali del midollo osseo possono differenziarsi in cartilagine. Studi precedenti dimostrano che le cellule seminate in idrogel senza l'inclusione di fibre sperimentano una contrazione cellulo-mediata che porta rapidamente alla morte cellulo-mediata; le fibre sono anche considerate la chiave per migliorare la resistenza meccanica degli idrogel. Tuttavia, dopo tre settimane in vitro in una matrice 3-D di gel di collagene, le cellule seminate in gel senza fibre non avevano percentuali di vitalità cellulare significativamente diverse rispetto alle cellule seminate in gel con fibre piatte o rotonde. Inoltre, le prove di compressione al 10% di deformazione hanno indicato che le sollecitazioni di equilibrio dei gel senza fibre erano significativamente superiori alle sollecitazioni di equilibrio dei gel contenenti fibre piatte. Pertanto, l'inclusione delle fibre e l'uso del condizionamento della stimolazione di compressione non può essere più efficace dei semplici costrutti di gel di collagene a base di semi di cellule.


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Product Details
  • ISBN-13: 9786202833103
  • Publisher: Edizioni Sapienza
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 254 gr
  • ISBN-10: 6202833106
  • Publisher Date: 04 Sep 2021
  • Height: 229 mm
  • No of Pages: 132
  • Spine Width: 8 mm
  • Width: 152 mm


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