Preface.- 1. Data Mining Strategies Applied in Brain Injury Models (S. Mondello, F. Kobeissy, I. Fingers, Z. Zhang, R.L. Hayes, K.K.W. Wang).- Application of Decomposition Methods in the Filtering of Event Related Potentials (K. Michalopoulos, V. Iordanidou, M. Zervakis).- 3. EEG Features as Biomarkers for Discrimination of Pre-ictal states (A. Tsimpiris, D. Kugiumtzis).- 4. Using Relative Power Asymmetry as a Biomarker for Classifying Psychogenic Non-epileptic Seizure and Complex Partial Seizure Patients (J.H. Chien, D.-S. Shiau, J.C. Sackellares, J.J. Halford, K.M. Kelly, P.M. Pardalos).- 5. Classification of Tree and Network Topology Structures in Medical Images (A. Skoura, V. Megalooikonomou, A. Diamantopolous, G.C. Kagadis, D. Karnabatidis).- 6. A Framework for Multi-Modal Imagin Biomarker Extraction with Application to Brain MRI (K. Maria, V. Sakkalis, N. Graf).- 7. A Statistical Diagnostic Decision Support Tool Using Magnetic Resonance Spectroscopy Data (E. Tsolaki, E. Kousi, E. Kapsalaki, I. Dimou, K. Theodorou, G. C. Manikis, C. Kappas, I. Tsougos).- 8. Data Mining for Cancer Biomarkers with Raman Spectroscopy (M.B.Fenn, V. Pappu).- 9. Nonlinear Recognition Methods for Oncological Pathologies (G. Patrizi, V. Pietropaolo, A. Carbone, R. De Leone, L. Di Giacomo, V. Losaco, G. Patrizi).- 10. Studying Connectivity Properties in Human Protein Interation Network in Cancer Pathway (V. Tomaino, A. Arulselvan, P. Veltri, P.M. Pardalos).- 11. Modeling of Oral Cancer Progression Using Dynamic Bayesian Networks (K.P. Exarchos, G. Rigas, Y. Golestsis, D.I. Fotiadis).- 12. Neuromuscular Alterations of Upper Airway Muscles in Patients with OSAS Radiological and Histopathological Findings (P. Drakatos, D. Lykouras, F. Sampsonas, K. Karkoulias, K. Spiropoulos).- 13. Data Mining System Applied to Population Databases for Studies on Lung Cancer (J. Pérez, F. Henriques, R. Santaolaya, O. Fragoso, A. Mexicano).