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Differenziazione delle cellule staminali mesenchimali delle cellule muscolari lisce

Differenziazione delle cellule staminali mesenchimali delle cellule muscolari lisce


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About the Book

La cardiopatia valvolare è un importante problema sanitario e socioeconomico in tutto il mondo, con circa 300.000 sostituzioni di valvole effettuate ogni anno. Le valvole cardiache ingegnerizzate con tessuti con capacità di riparazione e rimodellamento potrebbero superare i limiti delle attuali protesi valvolari. Una grande limitazione a questo approccio è stata trovare una fonte affidabile di cellule muscolari lisce (SMC) perché le biopsie di queste cellule possono essere poco pratiche e morbose e presentano anche una capacità replicativa limitata. La fonte cellulare ideale dovrebbe essere raccolta in modo non invasivo o minimamente invasivo e dovrebbe fornire un numero iniziale elevato di cellule al fine di ridurre drasticamente il tempo necessario per l'espansione cellulare. Per queste ragioni ci sono molti studi che si sforzano di esplorare se le SMC funzionali possono essere generate da vari tipi di cellule staminali mesenchimali adulte (MSC): Cordone ombelicale (UC-MSC), midollo osseo (BM-MSC), derivati adiposi (AD-MSC) e villi coriali (CV-MSC) come possibili fonti per la terapia delle valvole cardiache. Le MSC da diverse fonti sono state isolate ed espanse da donatori sani e diversi.


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Product Details
  • ISBN-13: 9786204065977
  • Publisher: Edizioni Sapienza
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 204 gr
  • ISBN-10: 6204065971
  • Publisher Date: 06 Sep 2021
  • Height: 229 mm
  • No of Pages: 96
  • Spine Width: 6 mm
  • Width: 152 mm


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