Part I: Introduction
1. Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research
Nabil Noureddin and Neil Kaplowitz
Part II: In Silico and Modeling Approaches
2. Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery
Francois Pognan
3. Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction
Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, and Weida Tong
4. Physicochemical Properties and Structural Alerts
Lilia Fisk, Nigel Greene, and Russ Naven
5. Quantitative Structure-Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans
Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, and Weida Tong
6. An Introduction to DILIsym(R) Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury
Christina Battista, Brett A. Howell, Scott Q. Siler, and Paul B. Watkins
Part III: In Vitro Technologies
7. Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities
Franck A. Atienzar and Jean-Marie Nicolas
8. Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury
Zhen Ren, Si Chen, Baitang Ning, and Lei Guo
9. Evaluation of Drug-induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches
Albert P. Li
10. Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing
Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, and Christopher E.P. Goldring
11. Engineered Human Liver Co-Cultures for Investigating Drug-Induced Liver Injury
Chase P. Monckton, and Salman R. Khetani
12. Status and Future of 3D Cell Culture in Toxicity Testing
Monicah A. Otieno, Jinping Gan, and William Proctor
13. Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design
Axel Pähler
14. In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury
Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, and Annie Borgne-Sanchez
15. Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches
Ruitang Deng
16. High Content Screening for Prediction of Human Drug-Induced Liver In
