It is a well-known fact of neurophysiology that neuronal responses to identically presented stimuli are extremely variable. This variability has in the past often been regarded as "noise." At the single neuron level, interspike interval (ISI) histograms constructed during either spontaneous or stimulus evoked activity reveal a Poisson type distribution. These observations have been taken as evidence that neurons are intrinsically "noisy" in their firing properties. In fact, the use of averaging techniques, like post-stimulus time histograms (PSTH) or event-related potentials (ERPs) have largely been justified based on the presence of what was believed to be noise in the neuronal responses.
More recent attempts to measure the information content of single neuron spike trains have revealed that a surprising amount of information can be coded in spike trains even in the presence of trial-to-trial variability. Multiple single unit recording experiments have suggested that variability formerly attributed to noise in single cell recordings may instead simply reflect system-wide changes in cellular response properties. These observations raise the possibility that, at least at the level of neuronal coding, the variability seen in single neuron responses may not simply reflect an underlying noisy process. They further raise the very distinct possibility that noise may in fact contain real, meaningful information which is available for the nervous system in information processing.
To understand how neurons work in concert to bring about coherent behavior and its breakdown in disease, neuroscientists now routinely record simultaneously from hundreds of different neurons and from different brain areas, and then attempt to evaluate the network activities by computing various interdependence measures, including cross correlation, phase synchronization and spectral coherence. This book examines neuronal variability from theoretical, experimental and clinical perspectives.

About the Author:
Mingzhou Ding is J. Crayton Pruitt Family Professor in the Department of Biomedical Engineering at the University of Florida. His past work dealt with nonlinear dynamical systems and stochastic processes. Currently, he is interested in cognitive neuroscience and related computational and signal processing problems.

Dennis Glanzman is Chief of the Theoretical and Computational Neuroscience Research Program at the National Institute of Mental Health, where he oversees a portfolio focused on the development and application of realistic models for the analysis and understanding of brain function. He was co-organizer of the joint NIH-NSF "Collaborative Research in Computational Neuroscience" Program which supports innovative interdisciplinary collaborative research to make significant advances in the understanding of nervous system function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.