Eicosanoids, Aspirin, and Asthma

Blending basic science with the latest clinical insights, this important book presents new ideas on the molecular biology, biochemistry, crystallography, and pharmacology of eicosanoids, including their interaction with antiinflammatory drugs and their influence on the mechanisms of asthma. Surveys a rich panorama of clinical symptoms from the European Network on Aspirin-Induced Asthma, the largest database of its kind in the world! Edited by clinicians with long experience in the field, Eicosanoids, Aspirin, and Asthma elucidates basic asthma mechanisms such as genetic influences, viruses, ion airway transport, and autoimmunity profiles the effectiveness of corticosteroids and aspirin desensitization in asthma treatment devotes special attention to aspirin-induced asthma reveals new details on the mechanisms of action of anti-inflammatory drugs provides evidence for the pneumoprotective action of endogenous nitric oxide highlights recent applications of crystallography in the understanding of the three-dimensional structure of cyclooxygenase describes new pathways of arachidonic acid metabolism explores the clinical manifestations in aspirin-induced asthma and more! Complete with over 2000 references, Eicosanoids, Aspirin, and Asthma will be welcomed by pulmonologists and pulmonary physicians, pulmonary rehabilitation therapists, respiratory physiologists, immunologists, allergists, pharmacologists, internists, chest physicians, otolaryngologists, pediatricians, molecular and cell biologists, epidemiologists, neuroanatomists, biochemists, and graduate and medical school students in these disciplines.

Table of Contents:
Mechanism of Action of Antiinflammatory Drugs, John R. Vane and Regine M. Botting Pathways of Arachidonate Metabolism, John C. McGiff and Michael Balazy Cytochromes P450 and Arachidonic Acid Metabolism, Michael Balazy and John C. McGiff Mechanisms of Isoprostane Biosynthesis in Humans, Paola Patrignani, Roberto Padovano, Maria Gina Sciulli, Giovanna Santini, Maria Rosaria Panara, Maria Teresa Rotondo, Giulia Renda, and Carlo Patrono Intracellular Localization of Eicosanoid-Forming Enzymes, Thomas G. Brock and Marc Peters-Golden Cyclooxygenase-2 Expression in Airway Cells, Peter J. Barnes, Maria G. Belvisi, Robert Newton, and Jane A. Mitchell Cyclooxygenase Gene Expression and Regulation, Kenneth Kun-yu Wu NSAID-Induced Apoptosis: A New Therapeutic Activity of Competitive Cyclooxygenase Inhibitors?, Daniel L. Simmons The Three-Dimensional Structure of Cyclooxygenases, Daniel Picot The Role of 5-Lipoxygenase Products in a Mouse Model of Allergic Airway Inflammation, Colin D. Funk, Xin-Sheng Chen, Charles G. Irvin, Yuan-Po Tu, and James R. Sheller Genetic Influences on Asthma, William O. C. M. Cookson Intrinsic Asthma, Leonardo M. Fabbri, Gaetano Caramori, Bianca Beghè, and Cristina Mapp Viral Infection and Asthma: The Modulatory Role of Nitric Oxide on Prostaglandin H Synthase, Gert Folkerts and Frans P. Nijkamp The Pharmacology of Prostaglandin E2: Actions in Human Diseases Involving the Mast Cell, John A. Oates, John J. Murray, David D. Hagaman, James R. Sheller, Ryszard Dworski, and L. Jackson Roberts II, and Howard R. Knapp Eicosanoids in the Pathogenesis of Exercise- and Allergen-Induced Asthma, Paul M. O'Byrne Endotoxin-Induced Acute Respiratory Distress Syndrome in Nitric Oxide-Deficient Rats, Pawel P. Wolkow, Ewa Janowska, Joanna B. Bartus, Wojciech Uracz, and Ryszard J. Gryglewski Eicosanoid Regulation by Glucocorticoids in Asthma, Ryszard Dworski Mechanisms of Aspirin-Induced Asthma, Andrzej Szczeklik Leukotrienes in Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. Lee Mast Cell and Eosinophil Responses After Indomethacin in Asthmatics Tolerant and Intolerant to Aspirin, Esther L. Langmack and Sally E. Wenzel Aspects of Mechanisms in Aspirin-Intolerant Asthma, Barbro Dahlén Aspirin-Intolerant Asthma: New Insights from Bronchial Mucosal Biopsies, Anthony P. Sampson Pharmacological Intervention in Generation of Leukotrienes by Eosinophils, Klaus F. Rabe and Gordon Dent Airway Ion Transport Mechanisms and Aspirin in Asthma, Sebastiano Bianco, Maria Robuschi, Adriano Vaghi, and Piersante Sestini Role of Autoantibodies Against Endothelial Cells in Severe Asthma, Philippe Lassalle, Michel Joseph, and Andre-Bernard Tonnel Clinical Course of Aspirin-Induced Asthma: Results of AIANE, Ewa Nizankowska, Mariusz Duplaga, Grazyna Bochenek, and Andrzej Szczeklik Nasal Polyposis, Niels Mygind, Ronald Dahl, Per L. Larsen, Torben Lildholdt, and Claus Bachert The Nose in Aspirin-Sensitive Asthma, César Picado and Joaquim Mullol The Role of Glucocorticoids in the Modulation of Eicosanoid Metabolism in Asthma, Isabelle Vachier, Pascal Chanez, Claude Chavis, Jean Bousquet, and Philippe Godard Desensitization in Aspirin-Induced Asthma, Donald D. Stevenson