The Epothilones: An Outstanding Family of Anti-Tumor Agents
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The Epothilones: An Outstanding Family of Anti-Tumor Agents

The Epothilones: An Outstanding Family of Anti-Tumor Agents


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About the Book

Preface General Aspects: Epothilon History - Natural Epothilones Biosynthesis and Heterologous Products of Epothilones: Introduction - Feeding Studies and the Discovery of Natural Epothilone Variants - Identification of the Epothilone Biosynthesis Gene Cluster - Studies in vitro of the Biochemistry of Epothilon Assembly - Heterologous Expression and Genetic Engineering of the Epothilone Biosynthesis Gene Cluster - Nutrient Regulation in S. cellulosus and M. Xanthus - Conclusions Total Synthesis of the Naturally Occurring Epothilones A-F: Introduction - Synthesis Approaches to both the Epothilones A/C- and B/D Series - Syntheses of Epothilone A/C (1a, 2a) - Synthesis of Epothilones B/D (1b, 2b) - Synthesis of Fragments - Semisynthetic Degradation/Reconstruction of 2b - Syntheses of Epothilones E and F (1c, 1d) and their 12, 13-Deoxyderivatives (2c, 2d) - Nicolaou's Synthesis of Epothilone Analogues - Conclusions Semisynthetic Derivatives of Epothilones: Introduction - Modification of the O16-C8 Sector (Polyketide Sector) - Modification of the Epoxide Moiety - Side Chain Modification - Removal/Incorporation of the C13-C16 Segment - Conclusion Applications: Preclinical Pharmaceutical and Structure-Activity Relationships of Epothilones - Clinical Studies with Epothilones References


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Product Details
  • ISBN-13: 9783211999288
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: Softcover of orig. ed.
  • Language: English
  • Returnable: N
  • Spine Width: 14 mm
  • Weight: 435 gr
  • ISBN-10: 3211999280
  • Publisher Date: 19 Oct 2010
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 260
  • Series Title: Fortschritte Der Chemie Organischer Naturstoffe Progress in
  • Sub Title: From Soil to the Clinic
  • Width: 156 mm


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