Essential Pediatric Oncology Book by Rakesh Mondal
Essential Pediatric Oncology

Essential Pediatric Oncology


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International Edition


About the Book

This book is a comprehensive guide to paediatric oncology for trainees and practising clinicians. Beginning with an introduction to epidemiology and cytogenetics, the following chapters discuss different varieties of childhood cancer, covering their etiology, classification, clinical features, diagnosis, treatment and prognosis. The book then examines issues such as imaging, radiation therapy, oncologic emergencies, stem cell transplant, palliative care, and cancer vaccines. The final chapters include discussion on evidence-based paediatric oncology practice, taken from The Cochrane Library (a collection of six databases that contain different types of high-quality, independent evidence to inform healthcare decision-making - www.thecochranelibrary.com), as well as Frequently Asked Questions from a parent's perspective. Key points Comprehensive guide to paediatric oncology Covers diagnosis and treatment of numerous varieties of childhood cancer Discussion on evidence-based practice from The Cochrane Library Includes FAQs from a parent's perspective

Table of Contents:
1. History of Pediatric Oncology 1 Sunil Natha Mhaske 2. Epidemiology of Childhood Cancer 9 Astha Tiwari, Sumantra Sarkar Risk Factors 9; Incidence of childhood cancer 9; Cancer types 10; Variation in sex 10; Incidence trends of childhood cancers 11; Survival rate 11 3. Immune Biology of Malignancy 12 Rakesh Mondal, Anirban Chatterjee The mechanism for prevention of neoplasia 12; Immunoediting 13; Genetics of immunomalignancy 14; Immune mediators of immunomalignancy 14; Anticancer antibodies and cytokines 15; Immunotherapy 16; Apoptosis 17; Malignant disorder of the immune system 18; Normal B cell ontogeny 18; Normal T cell ontogeny 18 4. Cytogenetics in Pediatric Cancers 20 Anup Kumar Roy, Anjan Das, Rakesh Mondal Basic genetics 20; Genetic predisposition to cancer 24 5. Flow Cytometric Immunophenotyping in the Diagnosis of Acute Leukemias 28 Arnab Chattopadhyay Flow cytometry immunophenotyping (FCI) guideline 28; Procedure 29; Uses 29; Limitation 31 6. Chemotherapy in Pediatric Oncology 34 Rakesh Mondal, Suhas Ganguly General principles of cancer chemotherapy 34; Antineoplastic agents used in pediatric oncology 36 7. Acute Lymphoblastic Leukemia 42 Supratim Datta, Kalpana Datta Etiology 42; Classification 42; Cytochemical characteristics 43; Clinical features 43; Diagnosis 44; Clinical and biological factors predicting outcome 44; Management 45 8. Hodgkin’s Disease 47 Anirban Chatterjee Epidemiology 47; Clinical features 47; Diagnosis 48; Pathology 48; Pathological classification of hd 49; Staging 49; Prognosis 50; Intervention 50 9. Non-Hodgkin’s Lymphoma in Children 54 Prantar Chakrabarti Classification and clinical presentation 54; Burkitt and Burkitt-like lymphoma/leukemia 55; Diffuse large B cell lymphoma 56; Lymphoblastic lymphoma 56; Anaplastic large cell lymphoma 57; Lymphoproliferative disease associated with immunodeficiency in children 57; Rare non-Hodgkin lymphoma occurring in children 58 10. Myeloid Leukemia in Children 69 Mousumi Nandi, Sandip Samanta Acute myeloid leukemia (aml) in children 69; Chronic myeloid leukemia (cml) in children 72; Stem cell transplant (SCT) 75 11. Pediatric Myelodysplastic Syndrome 79 Rajib De Difference from adult MDS 79; Diagnosis of MDS 79; Clinical features 79; Morphologic consideration 80; Classification 81; Secondary MDS 84 Contents xx | Essential Pediatric Oncology 12. Pediatric Histiocytic Disorders 88 Madhusmita Sengupta, Rakesh Mondal Classification of histiocytosis syndromes in children 88; Classification of histiocytosis syndromes from the histiocyte society 88; Hemophagocytic lymphohistiocytoses (HLH) 94; Rosai-Dorfman disease 95 13. Pediatric Solid Tumors 97 Bishwanath Mukhopadhyay Wilms’ tumor or nephroblastoma 97; Neuroblastoma 98; Scope of further improvement 101 14. Adrenal Tumors 102 Rakesh Mondal, Krishnendu Mukherjee Incidence and prevalence 102; Signs and symptoms 102; Diagnosis 103; Treatment 103; Prognosis 104 15. Pheochromocytomas 105 Rakesh Mondal, Pranab Sahana Incidence 105; Clinical features 105; Differential diagnosis 106; Diagnosis 106; Drug therapy 106; Surgery 107; Radiation therapy 107; Adjuvant therapies 108; Prognosis 108 16. Soft Tissue Sarcoma 110 Rakesh Mondal, Pradip Kumar Mitra Risk factors for soft tissue sarcomas in children 110; Symptoms of sarcoma 111; Types of sarcoma 111; Diagnosis and treatment 112; Rhabdomyosarcoma 113; Non-Rms soft tissue sarcomas (Nrsts) in children 116 17. Brain Tumor 118 Rakesh Mondal, Amitava Chandra Signs and symptoms 118; Different types of tumors 118; Diagnosis of brain tumors 121; Management of brain tumors 122 18. Bone Tumor 125 Anirban Chatterjee; Alok Shobhan Datta Osteosarcoma 125; Ewing sarcoma 128 19. Neoplasms in Neonates 134 Sumantra Sarkar Etiology 134; Clinical features 134; Discussion of individual tumors 134 20. Adolescent Oncology 139 Nibedita Chatterjee, Dipankar Gupta, Goutam Mukherjee Etiology 141; Symptoms and signs 141; Diagnostic imaging and pathology considerations 141; Management 142; Paucity of clinical trials 142 21. Ovarian Germ Cell Tumor 143 Goutam Mukherjee, Nibedita Chatterjee, Kakoli Chowdhury Etiology 143; Genetics and molecular biology 143; Epidemiology 143; Pathology 143; Clinical features 144; Individual tumors 145; Endodermal sinus tumor (est) 145; Diagnosis 146; Treatment 146; Treatment options by stages 148; Prognosis 149 22. Breast Cancer 151 Diptendra Sarkar, Subhayan Mandal, Nibedita Chatterjee, Rakesh Mondal Epidemiology and risk factors 151 23. Miscellaneous Neoplastic Disorders in Children (Hepatoblastoma/Retinoblastoma/Germ Cell Tumors) 153 Rakesh Mondal, Jayanta Dasgupta, Jayanta Ghosh Hepatoblastoma 153; Retinoblastoma 153; Germ cell tumors 156 24. Rare Carcinomas in Pediatric Oncology 158 Rakesh Mondal Hepatocellular carcinoma 158; Adenocarcinoma of the colon and rectum 158; Renal cell carcinoma 160; Thymic tumors and thymoma 160; Nasopharyngeal carcinoma 161; Thyroid tumors 161; Basal cell carcinoma 162; Melanoma 162 Contents | xxi 25. Opportunistic Infection in Pediatric Oncology 164 Rakesh Mondal Pathogens 164; Common opportunistic infection encountered 164 26. Immunization and Antibiotic Policy in Pediatric Oncology 167 Jaydeep Chowdhury Immunization in children with malignancies 167 27. Transfusion Practice in Pediatric Oncology: Blood and Blood Component Therapy 171 Rakesh Mondal Whole blood 171; Indications 171; Packed red blood cell 171; Guidelines for pediatric red blood cell transfusion 171; Fresh frozen plasma 172; Platelet 172; Others granulocyte transfusion 172; Infectious complications 174 28. Corticosteroid in Childhood Cancer 177 Abhisekh Roy, Rakesh Mondal Classification 177; Modes of action and indications in various pediatric cancers 177; Adverse drug reactions 178; Recent updates 178; Titbits 179 29. Nuclear Medicine Practices in Pediatric Oncology 180 Rakesh Mondal, Sumantra Sarkar Objective 180; Diagnostics 181; Therapeutics 182 30. Radio Imaging in Pediatric Oncology 184 Tapan Dhibar, Rakesh Mondal Imaging tests applied to pediatric oncology 184; Imaging in different tumors 185 31. Radiation in Pediatric Oncology 187 Kakoli Chowdhury, Anup Majumdar Role of RT in treatment of pediatric cancer 187 32. Pediatric Oncologic Emergencies 193 Dipankar Gupta Infectious emergencies 193; Inflammatory emergencies 195; Hematological emergencies 195 33. Intensive Care Issues in Pediatric Oncology Patients 207 Agni Sekhar Saha The interface between pediatric oncology and pediatric intensive care medicine 207; Overview 207; Complications requiring admission in PICU 208; Ethical considerations 212 34. Hematopoietic Stem Cell Transplant 214 Arpita Bhattacharya 35. Growth Factors and Biologicals in Pediatric Oncology 221 Madhumita Nandi Biologicals in cancer supportive care 221; Biologicals for therapeutics 224 36. Nutritional Support in Pediatric Cancer Patient 228 Anirban Chatterjee Etiology 228; Pathophysiology 228; Clinical assessment 229; Nutritional intervention technique 230 37. Palliative Care in Pediatric Oncology 232 Madhumita Nandi Communication and decision making 232; Cancer-directed therapy 233; Symptom assessment and control 233; When death is imminent 234; Bereavement 235 38. Psychosocial Issues in Pediatric Oncology 236 Rakesh Mondal, Nibedita Chatterjee Childhood cancers related to psychological issues 236; Mental health problem and childhood cancers 237; Childhood cancers mimicking the psychiatric disorders 238 39. Nursing Practices in Pediatric Oncology 240 Madhumita Nandi, Dipti Bhattacharya Clinical 241; Quality improvement initiatives 242; Leadership 242; Education 242; Professional development 242; Future implications 242 xxii | Essential Pediatric Oncology 40. Managing Pediatric Cancer Patients with Limited Resources 244 Sanat Ghosh Causes of treatment failure in resource poor countries 244; Requirements to improve the outcome 245 41. Training and Research in Pediatric Oncology 248 Rakesh Mondal, Ashish Mukherjee, Sumantra Sarkar What does a pediatric oncologist do? 248; Is pediatric oncology depressing? 248; What is the lifestyle of a pediatric oncology specialist? 249; What about remuneration? 249; What are the career choices for a pediatric oncology specialist? 249 Is it possible to further subspecialize in some aspects of oncology after receiving the general training? 249 42. Cancer Vaccines 252 Pragya Pant, Goutam Mukherjee, Toshibananda Bag What are cancer vaccines? 252; How do cancer preventive vaccines work? 252; What cancer preventive vaccines are available in the market? 253; Have other microbes been associated with cancer? 254; How are cancer treatment vaccines designed to work? 254; Tumor cell vaccines 254; Has the FDA approved any cancer treatment vaccines? 255; What types of vaccines are being studied in clinical trials? 255; What are the reasons for the high failure rates of therapeutic cancer vaccines? 255; What are the side effects of cancer vaccines? 255; Can cancer treatment vaccines be combined with other types of cancer therapy? 255; Vaccine for cervical carcinoma 255; Which girls/women should receive HPV vaccination? 256; Will sexually active females benefit from the vaccine? 256; Should girls and women be screened for cervical cancer before getting vaccinated? 256; Effectiveness of the HPV vaccines 256; How long does vaccine protection last? 256; What does the vaccine not protect against? 256; Safety of the HPV vaccine 256; Will girls/women who have been vaccinated still need cervical cancer screening? 256; Are there other ways to prevent HPV? 256; Cancer vaccines in pediatrics 256; Human papilloma virus 257; Hepatitis B vaccine 257 43. Biomedical Statistics: A Snapshot 259 Avijit Hazra Data types 259; Descriptive statistics 260; Measuring disease frequency 260; Determining sample size 261; Hypothesis testing 261; Comparing groups: Numerical variables 262; Comparing groups: Categorical variables 262; Association between variables 263; Statistics of diagnostic tests 263; Assessing risk 264; Survival analysis 264; The general linear model and other multivariate methods 266 44. Childhood Cancer Survivors 268 Madhumita Nandi Types of late effects 268 45. Evidence-based Pediatric Oncology Practice 275 Madhumita Nandi Effects of radiation on testicular function in long-term survivors of all 276; Effects of radiation on ovarian function in long-term survivors of childhood acute lymphoblastic leukemia 276; Long-term neuropsychologic sequelae of childhood leukemia: comparison 276; Long-term effects of cranial radiation therapy on attention functioning in survivors of childhood leukemia 277; Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia 277; Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia 278; Efficacy of postinduction intensification chemotherapy regimens in preventing relapse in all 278; Colony stimulating factors for chemotherapy induced febrile neutropenia 278; Colony stimulating factors for prevention of myelosuppressive therapy induced febrile neutropenia in children with acute lymphoblastic leukemia 279; The effect of cytokines G-CSF and GM-CSF in therapy of childhood malignancies 279; Improvement in treatment of childhood acute lymphoblastic leukemia: a 10-year study by the children’s cancer and leukemia study group 280; Treatment strategy and results in children treated on three Dutch childhood oncology group acute myeloid leukemia trials 280; Different anthracycline derivatives for reducing cardiotoxicity in cancer patients 281; Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy 281; Interventions for early stage Hodgkin’s disease in children 282; Chemotherapy, radiotherapy and combined modality for Hodgkin’s disease, with emphasis on second cancer risk 282; Therapeutic interventions for Burkitt’s lymphoma in children 283; Prospective study of 90 children requiring treatment for juvenile myelomonocytic leukemia or myelodysplastic syndrome: a report from the children’s cancer group 283; Contents | xxiii Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms’ tumor 283; Influence of surgery and radiotherapy on growth and pubertal development in children treated for brain tumor 284; Interventions for improving communication with children and adolescents about their cancer 285; Surviving cancer competently intervention program (SCCIP): A cognitive-behavioral and family therapy intervention for adolescent survivors of childhood cancer and their families 285 46. Frequently Asked Questions: Patient and Parents’ Perspective 287 Rakesh Mondal, Biman Roy 47. Modern Technology and Childhood Cancers—The Interface 291 Indira Banerjee, Ajay Ghosh, Rakesh Mondal Telecommunication devices (Prototype: Phone) 292; Waste management 294; Full body scanner used for air passengers 294; Nuclear power plant 294; Diagnostic radiology 294; Micro-oven 294 Annexure 1: Common Chemotherapy Protocols 297 Annexure 2: Antiemetic Principles 300 Annexure 3: Safe Handling of Hazardous Drugs 301 Annexure 4: Management of Drug Extravasations 302 Index 303


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Product Details
  • ISBN-13: 9789351529781
  • Publisher: Jp Medical Ltd
  • Publisher Imprint: Jp Medical Ltd
  • Edition: 1
  • Language: English
  • Returnable: N
  • Weight: 1250 gr
  • ISBN-10: 9351529789
  • Publisher Date: 30 Nov 2015
  • Binding: Paperback
  • Height: 279 mm
  • No of Pages: 320
  • Spine Width: 0 mm
  • Width: 216 mm


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