This handbook is a guide for workers in analytical chemistry who need a starting place for information about a specific instrumental technique. It gives a basic introduction to the techniques and provides leading references on the theory and methodology for an instrumental technique. This edition thoroughly expands and updates the chapters to include concepts, applications, and key references from recent literature. It also contains a new chapter on process analytical technology.

Dr. Nelu Grinberg recently retired following a distinguished career in research chemistry in the pharmaceutical industry. His research in analytical chemistry has emphasized chromatography, spectroscopy, and chiral separations. He was a Distinguished Research Fellow in the Chemical Development Department at Boehringer Ingelheim Pharmaceuticals in Ridgefield, CT until January 2017. Prior to this, he worked for sixteen years in the Analytical Department at Merck Research Laboratories in Rahway, NJ, where he was a Senior Research Fellow. Dr. Grinberg has authored and co-authored over 150 publications, including articles and book chapters, and has lectured and conducted courses worldwide. He is currently Editor-in-Chief of the Journal of Liquid Chromatography and Related Techniques, Editor of the Chromatographic Science book series, Editor of the Supramolecular book series, and Co-editor of the Advances in Chromatography series. He is also a member of the Board of the Connecticut Separation Science Council and was a recipient of a Koltoff Fellowship of the Hebrew University of Jerusalem. Dr. Grinberg obtained his Ph.D. in Chemistry from the Technical University of lasi in Romania. He conducted postdoctoral research with Professor Barry Karger at Northeastern University in Boston, Massachusetts, and with Professor Emanuel Gil-Av at The Weizmann Institute of Science in Rehovot, Israel.

Sonia Rodriguez studied Chemical Sciences at the Universitat Autònoma de Barcelona, Spain, where she received her Ph.D. in Organic Chemistry in 2000 under the supervision of Professors Pedro de March and Marta Figueredo. After a brief industrial experience at Finnovequim and Deripol, she decided to further broaden her synthetic background during a postdoctoral appointment with Prof. Peter Wipf at the University of Pittsburgh from 2001 to 2003. Subsequently, she worked in the department of Chemical Development at Boehringer Ingelheim Pharmaceuticals, Inc., with responsabilities in the Process Research and Catalysis groups. In 2017, Sonia joined the Process Chemistry group at FORMA Therapeutics, Inc. where she is also part of the CMC team.