1. Mechanisms of Drug-Induced Cholestasis
Eva Gijbels and Mathieu Vinken
2. LC-MS/MS Analysis of Bile Acids in In Vitro Samples
Debbie Dewaele, Pieter Annaert, and Eef Hoeben
3. Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis Amruta Damle-Vartak, Brigitte Begher-Tibbe, Georgia Gunther, Fabian Geisler, Nachiket Vartak, and Jan G. Hengstler
4. Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function
Pieter Van Brantegem, Neel Deferm, Bing Qi, Tom De Vocht, and Pieter Annaert
5. The C-DILI(TM) Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity
Jonathan P. Jackson and Kenneth R. Brouwer
6. In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids
Stef De Lombaerde, Sara Neyt, Christian Vanhove, and Filip De Vos
7. Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy
Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M.P. Rodrigues, Manuel Prieto, and Fábio Fernandes
8. The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis
Reza Heidari and Hossein Niknahad
9. Measuring Apoptosis and Necrosis in Cholestatic Liver Injury
Benjamin L. Woolbright and Hartmut Jaeschke
10. Necrosome Formation and Necroptosis in Experimental Cholestasis
Marta Bento Afonso and Cecília Maria Pereira Rodrigues
11. Proteomics in Primary Biliary Cholangitis
You Li, Ruqui Tang, Patrick S.C. Leung, Eric Gershwin, and Xiong Ma
12. Transcriptomics Analysis of Cholestatic Compounds In Vitro
Céline Parmentier, Philippe Couttet, Marianne Uteng, Armin Wolf, and Lysiane Richert
13. Systems Microscopy of Stress Response Pathways in Cholestasis Research
Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, and Bob van de Water
14. Mouse Models for Diseases in the Cholangiocyte Lineage
Noémi Van Hul, Urban Lendahl, and Emma R. Andersson
15. Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis
Sanne Van Campenhout, Hans Van Vlierberghe, and Lindsey Devisscher
16. 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research
Elisa
