Facteur de régulation de l'interféron 2 (IRF-2) murin et Escherichia coli
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Facteur de régulation de l'interféron 2 (IRF-2) murin et Escherichia coli

Facteur de régulation de l'interféron 2 (IRF-2) murin et Escherichia coli


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About the Book

Le facteur de régulation de l'interféron-2 est un facteur de transcription des vertébrés ayant un caractère oncogène; il antagonise les fonctions du facteur de régulation de l'interféron-1, un gène suppresseur de tumeur. Des souris knock-out pour le gène IRF-2 ont montré un défaut dans la lymphopoïèse des cellules B, elles sont mortes suite à des infections LCMV (Lymphocytic Choriomeningitis Virus). L'IRF-2 est fonctionnellement à l'opposé de l'IRF-1. Il est intéressant de noter que l'on aurait pu penser que, comme les souris IRF-1-/- (knock-out) présentaient un manque de cellules CD8+T et une faible cytotoxicité des cellules NK, la surproduction d'IRF-2 chez les souris pourrait les rétablir. Mais ce n'est pas le cas, la raison en étant inconnue. Cependant, l'IRF-2 se lie à la séquence de l'Interferon Stimulated Response Element dans les cellules infectées par un virus. Ce livre traite du clonage de l'ADNc du gène IRF-2 de la souris et de l'expression de la protéine chimérique dans E.coli. Cette étude servira de plate-forme pour une analyse fonctionnelle plus poussée de l'IRF-2 chimérique, qui est un oncogène puissant dans des conditions aberrantes.


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Product Details
  • ISBN-13: 9786205649824
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 6205649829
  • Publisher Date: 30 Jan 2023
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 163 gr


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Facteur de régulation de l'interféron 2 (IRF-2) murin et Escherichia coli
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