Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley’s Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Table of Contents:
VOLUME I 1 Developmental Biology, Organization, and Function of the Synovial Joints 2 Synovium 3 Cartilage and Chondrocytes Development and Biology of Bone 5 Muscle Anatomy, Physiology, and Biochemistry 6 Biomechanics 7 Regenerative Medicine and Tissue Engineering 8 Proteinases and Matrix Degradation 9 Dendritic Cells 10 Mononuclear Phagocytes 11 Neutrophils 12 T Lymphocytes 13 B Cells 14 Fibroblasts and Fibroblast-like Synoviocytes 15 Mast Cells and Basophils 16 Innate Lymphoid Cells and Natural Killer Cells 17 Platelets and Megakaryocytes 18 Principles of Signaling 19 Innate Immunity 20 Adaptive Immunity 21 Immune Tolerance and Autoimmunity 22 Pre-clinical Autoimmunity 23 The Microbiome in Rheumatic Diseases 24 Genetics of Rheumatic Diseases 25 Epigenetics of Rheumatic Diseases 26 Complement System 27 Prostaglandins, Leukotrienes, and Related Compounds 28 Angiogenesis 29 Cytokines and Chemokines 30 Neuronal Mechanisms of Pain and Inflammation 31 Clinical Research Methods in the Rheumatic Diseases 32 Epidemiology and Impact of Rheumatic Diseases 33 Assessment of Health Outcomes 34 Biomarkers in Rheumatology 35 Occupational, Environmental, and Recreational Musculoskeletal Disorders 36 Cardiovascular Risk in Inflammatory Rheumatic Disease 37 Cancer Risk in Rheumatic Diseases 38 Occupational Therapy, Physical Therapy, and Rehabilitation 39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment 40 History and Physical Examination of the Musculoskeletal System 41 Ultrasound in Rheumatology 42 Evaluation of Monoarticular and Polyarticular Arthritis 43 Skin and Rheumatic Diseases 44 The Eye and Rheumatic Diseases 45 Neck Pain 46 Shoulder Pain 47 Low Back Pain 48 Hip and Knee Pain 49 Foot and Ankle Pain 50 Hand and Wrist Pain 51 Temporomandibular Joint Disorders 52 Fibromyalgia 53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology 54 Arthrocentesis and Injection of Joints and Soft Tissues 55 Anti-nuclear Antibodies 56 Autoantibodies in Rheumatoid Arthritis 57 Acute Phase Reactants 58 Imaging in Rheumatic Diseases VOLUME II 59 Therapeutic Targeting of Prostanoids 60 Glucocorticoid Therapy 61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies 62 Immunosuppressive Drugs 63 Anti-cytokine Biologics 64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics 65 Janus Kinase and Other Intra-cellular Targets 66 Urate-Lowering Therapy 67 Bisphosphonates 68 Analgesic Agents in Rheumatic Disease 69 Nutrition and Rheumatic Diseases 70 Etiology of Rheumatoid Arthritis 71 Pathogenesis of Rheumatoid Arthritis 72 Clinical Features of Rheumatoid Arthritis 73 Treatment of Rheumatoid Arthritis 74 Sjögren’s Syndrome 75 Classification and Epidemiology of Spondyloarthritis 76 Axial Spondyloarthritis 77 Reactive Arthritis 78 Psoriatic Arthritis 79 Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies 80 Etiology and Pathogenesis of Systemic Lupus Erythematosus 81 Clinical Features of Systemic Lupus Erythematosus 82 Treatment of Systemic Lupus Erythematosus 83 Antiphospholipid Syndrome 84 Etiology and Pathogenesis of Systemic Sclerosis 85 Clinical Features and Treatment of Scleroderma 86 Inflammatory Diseases of Muscle and Other Myopathies 87 Overlap Syndromes 88 Classification and Epidemiology of Systemic Vasculitis 89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis 90 Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis 91 Polyarteritis Nodosa 92 Immune Complex-Mediated Small Vessel Vasculitis 93 Primary Central Nervous System Vasculitis 94 Behçet’s Disease 95 Pathogenesis of Inflammasome-Mediated Diseases 96 Etiology and Pathogenesis of Hyperuricemia and Gout 97 Clinical Features and Treatment of Gout 98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes 99 Familial and Nonfamilial Autoinflammatory Syndromes 100 Etiology and Pathogenesis of Osteoarthritis 101 Clinical Features of Osteoarthritis 102 Treatment of Osteoarthritis 103 Metabolic Bone Disease 104 Proliferative Bone Diseases 105 Osteonecrosis 106 Relapsing Polychondritis 107 Heritable Diseases of Connective Tissues 108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis 109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis 110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus 111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis 112 Bacterial Arthritis 113 Lyme Disease 114 Mycobacterial Infections of Bones and Joints 115 Fungal Infections of Bones and Joints 116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection 117 Viral Arthritis 118 Rheumatic Fever and Post-streptococcal Arthritis 119 COVID-19 and Rheumatic Disease 120 Vaccination in Rheumatic Disease 121 Amyloidosis 122 Sarcoidosis 123 Hemochromatosis 124 Hemophilic Arthropathy 125 Rheumatic Manifestations of Hemoglobinopathies 126 IgG4-Related Disease 127 Arthritis Accompanying Endocrine and 128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations 129 Tumors and Tumor-like Lesions of Joints and Related Structures 130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer