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Formulation & Développement de Lamotrigine Comprimé Orodispersible

Formulation & Développement de Lamotrigine Comprimé Orodispersible


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About the Book

La lamotrigine entre dans la catégorie des médicaments antiépileptiques. Il s'agit d'un médicament de classe II BCS qui est insoluble dans l'eau et dont la demi-vie est de 24 à 25 heures avec une biodisponibilité de 90 %. Pour obtenir une meilleure vitesse de dissolution in vitro de la lamotrigine en utilisant la technique Liquisolid, les comprimés Liquisolid ont été optimisés par l'approche QbD-DoE 32 plan factoriel complet à l'aide du logiciel Design Expert. Tous les lots liquisolid préparés ont été soumis à des tests de variation de poids, d'uniformité de la teneur en médicament, de dureté, de friabilité, de désintégration et de dissolution. Les systèmes liquisolides ont également été testés par DSC et FT-IR. D'après les résultats de l'analyse des points de contrôle des données de conception, LMLCODT1 montre une plus grande libération de médicament à LAMOTRIGINE moins de temps de mouillage et de désintégration (5,24 sec), ce qui augmente la solubilité de Lamotrigine de 4,73 mg/ml. Par conséquent, ce travail de recherche peut être utile pour formuler des comprimés orodispersibles à l'aide de la technique Liquisolid qui peut donner un début d'action rapide par une absorption rapide, maximiser l'efficacité, réduire la dose et la fréquence de la dose et donc augmenter l'observance du patient.


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Product Details
  • ISBN-13: 9786205823392
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 124
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 620582339X
  • Publisher Date: 23 Mar 2023
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 245 gr


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