Formulation d'un système d'administration de médicaments auto-micro-émulsifiant
Formulation d'un système d'administration de médicaments auto-micro-émulsifiant

Formulation d'un système d'administration de médicaments auto-micro-émulsifiant


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About the Book

Ce livre explique une méthode de préparation d'un système d'administration de médicaments auto-microémulsifiant (SMEDDS) d'un médicament peu soluble dans l'eau, le céfadroxil monohydraté. L'impact de l'huile, du surfactant et du co-surfactant sur la solubilité du médicament et leurs ratios pour former des SMEDDS efficaces et stables ont été examinés. La méthode de titrage à l'eau a été utilisée pour la formulation des SMEDDS. Les SMEDDS ont été caractérisés par l'observation morphologique, la taille des globules, la mesure du point de trouble, la détermination de la viscosité, l'indice de réfraction, la transmittance en %, la teneur en médicament des SMEDDS de cefadroxil monohydraté et l'étude de libération in vitro. La formulation optimale F2 était composée d'acide oléique, de tween-80 et de PEG-400 avec un rapport S mix. de 1:1. Le test de libération in vitro a montré une libération complète du cefadroxil monohydraté à partir du SMEDDS dans un délai d'environ 1,5 heure. Des formulations orales de SMEDDS de cefadroxil monohydraté ont été préparées pour permettre une excellente solubilisation du médicament et une meilleure libération in vitro du cefadroxil monohydraté par rapport au produit marqué. La formulation F2 sélectionnée a été testée pour des études pharmacocinétiques en comparaison avec la formulation commercialisée, ce qui a montré une augmentation de la biodisponibilité orale du cefadroxil monohydraté.


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Product Details
  • ISBN-13: 9786207863839
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 163 gr
  • ISBN-10: 6207863836
  • Publisher Date: 28 Jul 2024
  • Height: 229 mm
  • No of Pages: 104
  • Spine Width: 6 mm
  • Width: 152 mm


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Formulation d'un système d'administration de médicaments auto-micro-émulsifiant
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