Formulation and Evaluation of Extended Release Tablet of Divalproex
Home > Medicine > Other branches of medicine > Pharmacology > Medical toxicology > Formulation and Evaluation of Extended Release Tablet of Divalproex
Formulation and Evaluation of Extended Release Tablet of Divalproex

Formulation and Evaluation of Extended Release Tablet of Divalproex


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
About the Book

The present study was aimed to develop an extended release matrix tablet of Divalproex sodium using hydrophilic polymer as release retarding agent. The formulation of Divalproex sodium matrix forming tablet was developed by using 2 factor 3 level full factorial design. The concentrations of HPMC K100M (10%, 12.5% & 15%), Eudragit L100 (10%, 12.5% & 15%) were selected as independent variables. The dependent variables selected were %drug released at 3hr, and %drug released at 12hr. As the drug has good flow property and compressibility, the direct compression method was employed to formulate the tablets. Tablets were evaluated for various physicochemical parameters. In vitro drug release study showed that batch F8 (HPMC K100M-15%, Eudragit L100-10%) was found to be optimized as it had almost identical dissolution profile with marketed product. Eudragit show synergism with HPMC K100M on drug release retardation and avoid the chances of burst release. The kinetic release treatment showed that Korsmeyer equation has shown of r2 = 0.988. Stability study of optimized batch F8 was conducted at accelerated conditions for one month and it was found to be stable.


Best Sellers



Product Details
  • ISBN-13: 9783659245220
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 3659245224
  • Publisher Date: 15 Sep 2012
  • Height: 229 mm
  • No of Pages: 120
  • Series Title: English
  • Weight: 236 gr


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Formulation and Evaluation of Extended Release Tablet of Divalproex
Lap Lambert Academic Publishing -
Formulation and Evaluation of Extended Release Tablet of Divalproex
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Formulation and Evaluation of Extended Release Tablet of Divalproex

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!