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Formulazione e sviluppo della compressa orodispersibile di lamotrigina

Formulazione e sviluppo della compressa orodispersibile di lamotrigina


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International Edition


About the Book

La lamotrigina rientra nella categoria dei farmaci antiepilettici. È un farmaco di classe BCS II, insolubile in acqua, con un'emivita di 24-25 ore e una biodisponibilità del 90%. Per ottenere una maggiore velocità di dissoluzione in vitro della lamotrigina utilizzando la tecnica del liquisolidio, le compresse liquisolidi sono state ottimizzate mediante l'approccio QbD-DoE e il disegno fattoriale completo con il software Design Expert. Tutti i lotti liquisolidi preparati sono stati sottoposti a variazione di peso, uniformità del contenuto di farmaco, durezza, friabilità, disintegrazione e dissoluzione. I sistemi liquisolidi sono stati anche testati per DSC e FT-IR. Dai risultati dell'analisi dei punti di controllo dei dati di progettazione, LMLCODT1 mostra un rilascio di farmaco più elevato a LAMOTRIGINA con un tempo di bagnatura e un tempo di disintegrazione inferiori (5,24 sec) che aumentano la solubilità di Lamotrigina di 4,73 mg/ml. Pertanto, questo lavoro di ricerca può essere utile per formulare compresse orodispersibili utilizzando la tecnica del liquisolidio che può dare un rapido inizio d'azione attraverso un rapido assorbimento, massimizzare l'efficacia, ridurre la dose e la frequenza di somministrazione e quindi aumentare la compliance del paziente.


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Product Details
  • ISBN-13: 9786205823361
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 124
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 6205823365
  • Publisher Date: 23 Mar 2023
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 245 gr


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