Formulazione e valutazione di compresse galleggianti di quetiapina fumarato
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Formulazione e valutazione di compresse galleggianti di quetiapina fumarato

Formulazione e valutazione di compresse galleggianti di quetiapina fumarato


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About the Book

Il presente lavoro di ricerca riguarda le compresse galleggianti a matrice gastro-ritentiva di quetiapina fumarato utilizzando vari polimeri idrofili. La formulazione è stata sviluppata utilizzando diverse concentrazioni di polimeri di vari gradi di HPMC. È stata poi ottimizzata la concentrazione dell'agente gassoso bicarbonato di sodio. La miscela di formulazione è stata sottoposta a vari studi di preformulazione e tutte le formulazioni sono risultate buone, indicando che la miscela di polveri ha buone proprietà di flusso. Tra i diversi polimeri di controllo, HPMC K100M ha mostrato la più alta capacità di ritardare il rilascio di farmaco. La formulazione F2 ha mostrato risultati soddisfacenti. Per la formulazione F2 il valore dell'esponente di diffusione n è compreso tra 0,45 e 0,89, quindi segue il modello di diffusione molare non fickiana. Il diagramma di Higuchi per la formulazione F2 presenta buoni valori di correlazione, quindi il farmaco sta rilasciando un meccanismo di diffusione; non sono riusciti a ritardare il rilascio del farmaco fino a 12 ore. Questo libro, quindi, è utile agli studenti del progetto M. Pharmacy che sono interessati a lavorare nel GRDDS.


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Product Details
  • ISBN-13: 9786207267637
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 113 gr
  • ISBN-10: 620726763X
  • Publisher Date: 15 Mar 2024
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm


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