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Formulação e Avaliação de Nanogel para Artrite Reumatóide

Formulação e Avaliação de Nanogel para Artrite Reumatóide


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About the Book

As pomadas são feitas a partir de extractos de animais, minerais e plantas que eram amplamente utilizados nos cuidados de saúde egípcios e babilónicos em 3000 AC. A pele, a vagina, os olhos e o nariz são as principais vias de administração tópica que têm sido amplamente estudadas. A presente investigação baseou-se na formulação e avaliação do Nanogel de Etodolac para acção tópica na Artrite Reumatóide. O nanogel foi preparado utilizando um procedimento padrão e, em seguida, foi avaliado utilizando vários parâmetros, ou seja, pH, % de conteúdo do fármaco, aspecto físico, tamanho das gotículas e índice de polidispersão (PDI), libertação do fármaco in vitro, viscosidade, estabilidade e factor reumatóide. Nos resultados, apresentou um nanogel mais compatível quando formulado e avaliado para diferentes parâmetros. Mostrou uma melhor libertação do fármaco in-vitro e um potencial anti-artrite reumatóide quando diminuiu o factor reumatóide em ratos. Em conclusão, provou ser um potente agente anti-reumático para a artrite. O nanogel pode ser eficaz devido à sua melhor libertação do fármaco e aos seus parâmetros físico-químicos. Pode ser testado em ensaios clínicos e depois recomendado para a cura da artrite reumatóide (AR) em seres humanos.


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Product Details
  • ISBN-13: 9786206068600
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 88
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6206068609
  • Publisher Date: 06 Jun 2023
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 190 gr


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