Gabab Receptor Book by Giancarlo Colombo - Bookswagon
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Gabab Receptor

Gabab Receptor


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About the Book

1. Historical Perspectives on the GABAB Receptor.- Section 1. Chemistry.- 2. Chemistry of GABAB Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABAB Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABAB Receptor.- 5. Distribution and Localization of the GABAB Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABAB Receptor.- 7. Modulation of Neurotransmission by the GABAB Receptor.- 8. GABAB Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands.- 10. Targeting the GABAB Receptor for the Treatment of Epilepsy.- 11. Targeting the GABAB Receptor for the Treatment of Pain.- 12. Targeting the GABAB Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABAB Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABAB Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABAB Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABAB Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABAB Receptor Ligands.- 19. GABAB Receptor Antagonists as Cognition Enhancers.


About the Author:

Giancarlo Colombo is a researcher at the Neuroscience Institute, Section of Cagliari, National Research Council of Italy. He has previously worked at the Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA, and the Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.

His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and the development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.

He has published approximately 200 papers in peer-reviewed journals and about 20 book chapters. He serves on the editorial board of the journals Alcohol and Alcohol and Alcoholism.


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Product Details
  • ISBN-13: 9783319834283
  • Publisher: Humana Press
  • Publisher Imprint: Humana Press
  • Height: 234 mm
  • No of Pages: 385
  • Series Title: Receptors
  • Weight: 621 gr
  • ISBN-10: 3319834282
  • Publisher Date: 14 Jun 2018
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 21 mm
  • Width: 156 mm


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