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Genetically Engineered Mice for Cancer Research

Genetically Engineered Mice for Cancer Research


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About the Book

Foreword.- Preface.- Overview of Designing Genetically-Engineered Mouse Models.- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer.- Using Recombineering Technology To Create Genetically Engineered Mouse Models.- Insertional Mutagenesis for Generating Mouse Models of Cancer.- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer.- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat.- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology.- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer.- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry.- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing.- Imaging mouse models of human cancer.- Identifying Mammary Epithelial Stem and Progenitor Cells.- Differentiation Programs in Development and Cancer.- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse.- Mouse Models for Colorectal Cancer.- Src family tyrosine kinases: Implications for mammary tumor progression.- Maspin and Suppression of Tumor Metastasis.- Epigenetic Mouse Models.- Modeling Transforming Growth Factor-ß Signaling in Cancer.- Modeling Stromal-Epithelial Interactions.- Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.- Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models.- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models.- Animal Models for Breast Cancer Prevention Resarch.- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies.- Mouse Models in Preclinical Drug Development- Applications to CNS Models.- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine.- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development.- Index.


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Product Details
  • ISBN-13: 9781489991256
  • Publisher: Springer-Verlag New York Inc.
  • Binding: Paperback
  • Height: 229 mm
  • No of Pages: 632
  • Series Title: English
  • Sub Title: Design, Analysis, Pathways, Validation and Pre-Clinical Testing
  • Width: 155 mm
  • ISBN-10: 1489991255
  • Publisher Date: 03 Mar 2014
  • Edition: 2012 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 38 mm
  • Weight: 1001 gr


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