Part I: Introductory Chapters
1. Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders
Roslyn A. Bonar, Giuseppe Lippi, and Emmanuel J. Favaloro
2. Preanalytical Issues in Hemostasis and Thrombosis Testing
Giuseppe Lippi and Emmanuel J. Favaloro
3. The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing
Massimo Franchini
Part II: Routine Coagulation Assays
4. Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR)
Emmanuel J. Favaloro
5. Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants Geoffrey Kershaw
6. Performance and Interpretation of Mixing Tests in Coagulation
Geoffrey Kershaw
7. D-Dimer Testing: Laboratory Aspects and Current Issues
Jecko Thachil, Giuseppe Lippi, and Emmanuel J. Favaloro
8. Determination of Fibrinogen and Thrombin Time (TT)
Anetta Undas
Part III: Thrombophilia-Related Chapters
9. An Overview of Thrombophilia and Associated Laboratory Testing
Martina Montagnana, Giuseppe Lippi, and Elisa Danese
10. Laboratory Testing for Activated Protein C Resistance (APCR)
Soma Mohammed and Emmanuel J. Favaloro
11. Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing
Richard A. Marlar and Jana N. Gausman
12. Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing
Richard A. Marlar and Jana N. Gausman
13. Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing
Jana N. Gausman and Richard A. Marlar
14. Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT)
Vittorio Pengo, Elisa Bison, Alessandra Banzato, Giacomo Zoppellaro, Seena Padayattil Jose, and Gentian Denas
15. Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT)
Armando Tripodi and Veena Chantarangkul
16. Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies
Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris
17. Solid Phase Immunoassay for the Detection of Anti-β2 Glycoprotein I Antibodies
Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris
18. Measuring Direct Oral Anticoagulants
Robert C. Gosselin and Jonathan Douxfils
19. Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing
Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, and Emmanuel J. Favaloro
Part IV: Bleeding Disorders
20. One-Stage Factor VIII Assays
Elizabeth Duncan and Susan Rodgers
21. Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A
Susan Rodgers and Elizabeth Duncan
22. Assessment of Factor XIII
László Muszbek, Éva Katona, and Adrienne Ker